Leslie Benet, PhD

Education
Ph.D., 1965 - Graduate Division (Pharmaceutical Chemistry), University of California, San Francisco
Honors and Awards
  • Remington Honor Medal, American Pharmacists Association, 2016
  • Doctor of Philosophy, honoris causa, University of Lisbon, Portugal, 2016
  • William B. Abrams Lectureship, FDA/CDER and ASCPT, 2015
  • William B. Abrams Lectureship, FDA/CDER and American Society for Clinical Pharmacology and Therapeutics, 2015
  • North American Scientific Achievement Award, International Society for the Study of Xenobiotics, 2015
  • "25 Top Pharmacy Professors" in USA, Medical Technology Schools, 2015
  • Listed among "25 Top Pharmacy Professors" in the U.S.A., Medical Technology Schools, 2015
  • Guest Professorship, Sichuan University, Sichuan Province, China, 2014-2019
  • 1 of 16 pharmacologists worldwide to be listed in both 2001 and 2014 compilations, Thompson Reuters Highly Cited Researcher, 2014
  • Highly cited Researcher-Pharmacology, Thomson Reuters, 2014
  • AAPS Journal Manuscript Award for the Most Outstanding Manuscript, American Association of Pharmaceutical Scientists, 2013
  • 2013 APhA-APRS Ebert Prize, American Pharmacists Association Academy of Pharmaceutical Research and Science (APhA-APRS),, 2013
  • Busse Lecture, University of Wisconsin, 2013
  • Invited Plenary Lecture, CPSA Shanghai 2012: From Bench to Decision Making – From Basics to Applications, Shanghai, China, 2012
  • Honorary Member, Chinese Society of Clinical Pharmacy, Zhengzhou, China, 2012
  • Honorary Member, International Pharmaceutical Federation, The Netherlands, 2012
  • Invited Plenary Lecture, International Symposium on Past, Present and Future Molecular Pharmacokinetics, Tokyo, Japan, 2012
  • Invited Keynote Lecture, NRPB – AAPS Workshop on Clinical and Diagnostic Biomarkers, Taipei, Taiwan, 2012
  • Invited Keynote Lecture, Texas Tech University Health Science Center School of Pharmacy Research Days, Texas Tech University, 2012
  • Visiting Professor of the First Clinical Medical College of Zhengzhou University, and the Institute, Zhengzhou University, Henan Province, China, 2012
  • Distinguished Investigator Award, American College of Clinical Pharmacology, 40th Annual Meeting, Chicago, IL, 2011
  • The AstraZeneca Drug Hunting Lecture, AstraZeneca Research & Development Mölndal, Sweden, 2011
  • Invited Plenary Lecture, Symposium, Biomedical Centre, Uppsala University, Uppsala, Sweden, 2011
  • Inaugural Albert B. Prescott Distinguished Lecture, Horace Rackham School of Graduate Studies, University of Michigan, 2011
  • Named “National Associate”, National Research Council, 2011
  • Gerhard Levy Distinguished Lectureship in Pharmaceutical Sciences, State University of New York at Buffalo, 2011
  • Doctor of Science, honoris causa, University of Michigan, 2011
  • Invited Plenary Lecture, 18th International Symposium on Microsomes and Drug Oxidations, Beijing, China, 2010
  • Invited Plenary Lecture, 2010 Pharmaceutical Sciences World Congress and the AAPS Annual Meeting and Exposition, New Orleans,, 2010
  • Oscar B. Hunter Memorial Award in Therapeutics, American Society for Clinical Pharmacology and Therapeutics 111th Annual Meeting, Atlanta, Georgia, 2010
  • Doctor of Philosophy, honoris causa, Catholic University of Leuven, Leuven, Belgium, 2010
  • Elected Fellow, Controlled Release Society, 2010
  • Invited Keynote Lecture, The 42nd Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), The Ohio State University, 2010
  • Invited Plenary Lecture, 129th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Japan, 2009
  • Invited Plenary Lecture, 9th International Symposium of the Controlled Release Society Indian Chapter, Mumbai, India, 2009
  • Nagai Foundation Tokyo Distinguished Lectureship 2008, 2008
  • National Defense Medical Center, Taipei, 2008
  • Invited Keynote Speaker, 100th Anniversary of School of Pharmacy, NDMC; 2008 PST & TSHP Joint International Conference, 2008
  • Paul Ehrlich Magic-Bullet Award 2008 Lifetime Achievement, 100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich, Nürnberg, Germany, 2008
  • Invited Featured Speaker, 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, 2008
  • Invited Plenary Lecture, 28th Annual Meeting of the Japanese Society for Drug Delivery Systems, Tokyo, Japan, 2008
  • Keynote Lecture, 8th International Symposium on Advances in Technology & Business Potential of New Drug Delivery Syst, 2008
  • Invited Plenary Lecture, Modified Release Forum, West Point, PA, 2008
  • Chair, Scientific Advisory Board, iMED.UL (Research Institute for Medicines and Pharmaceutical Sciences) University of Lisbon, Portuga, 2008
  • Plenary Lecture, 7th International Symposium on Advances in Technology and Business Potential of New Drug Delivery Sy, 2007
  • Keynote Lecture, Biocomputing Day, Division of Biocomputing, School of Medicine, University of New Mexico, 2007
  • International Honorary Member, Japan Society for the Study of Xenobiotics, Sendai, Japan, 2007
  • Keynote Lecture, Meeting of the European Drug Absorption Network, Leuven, Belgium, 2007
  • UCSF 7th Distinguished Clinical Research Lecturer, University of California San Francisco, 2007
  • Graduation Speaker, University of Michigan College of Pharmacy, Ann Arbor, MI, 2007
  • Plenary Lecture, 16th International Symposium on Microsomes and Drug Oxidation, Budapest, 2006
  • Plenary Lecture, 4th International COE Symposium, Target Validation, Lead Optimization & Clinical Development, Tokyo, 2006
  • Plenary Lecture, Analytica Conference 2006, Munich, Germany, 2006
  • Plenary Lecture, Canadian Society for Pharmaceutical Sciences 9th Annual International Symposium on Pharmaceutical Sc, 2006
  • Chair, Gordon Research Conference on Drug Metabolism, Plymouth, NH, 2006
  • Keynote Address, Great Lakes Symposium 2006, Buffalo, NY, 2006
  • Plenary Lecture, Journees Galeniques de Saint-Remy de Provence, Saint-Remy, France, 2006
  • Plenary Lecture, 2nd International Symposium on Scientific & Regulatory Aspects of Dissolution & Bioequivalence, 2005
  • Plenary Lecture, 9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, 2005
  • Keynote Address, British Pharmaceutical Conference, Manchester, UK, 2005
  • Doctor of Philosophy, honoris causa, University of Athens, Greece, 2005
  • Career Achievement Award in Oral Drug Delivery, Controlled Release Society 2004 Annual Meeting & Exposition, 2004
  • Research Achievement Award in Pharmaceutical Sciences, Pharmaceutical Sciences World Congress 2004, Kyoto, 2004
  • Opening Plenary Lecture, First Congress of the Portuguese Society for Pharmaceutical Sciences, 2003
  • ISI Highly Cited Researcher, Institute for Scientific Information, 2003
  • Invested as a “Member of Honour”, Romanian Academy of Medical Sciences, 2003
  • Chair, IOM/NRC Committee on Accelerating the Research, Development and Acquisition, of Medical Countermeasures Against Biological Warfare Agents, 2002-2004
  • Plenary Lecture, 10th International Conference on Pharmaceutical Technology, Florence, Italy, 2002
  • Invested as a “Miembro Honorario”, Academia de Ciencias Farmacéuticas de Chile, Santiago, Chile, 2002
  • Plenary Lecture, International Pharmaceutical Technology Symposium 2002, Istanbul, Turkey, 2002
  • Elected Fellow, American Association of Indian Pharmaceutical Scientists, 2001
  • Høst-Madsen Medal, International Pharmaceutical Federation, 2001
Websites
Publications

  1. Benet LZ, Sodhi JK. Mathematical Modeling in Drug Metabolism and Pharmacokinetics: Correct In Vitro, Not Always Valid In Vivo. Pharmaceuticals (Basel, Switzerland) 2026. PMID: 41599757


  4. Benet LZ, Sodhi JK. Response to the commentary on "are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance?" European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025. PMID: 40174658


  5. Benet LZ, Sodhi JK, Tiitto MV, Xiang Y. Application of Kirchhoff's Laws to pharmacologic and pharmacokinetic analyses. Pharmacological reviews 2025. PMID: 40120204


  6. Benet LZ, Sodhi JK. Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff's Laws. Frontiers in pharmacology 2024. PMID: 39564109


  7. Yu Z, Liu W, Wang Z, Chen Y, Yan J, Benet LZ, Zhai S. Is there a possibility that P-glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not? Clinical and translational science 2024. PMID: 39356462


  8. Benet LZ, Sodhi JK. CommentaryPharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 2024. PMID: 38942444


  9. Benet LZ, Tiitto MV, Sodhi JK. The potential of developing high hepatic clearance drugs via controlled release: Lessons from Kirchhoff's Laws. Journal of controlled release : official journal of the Controlled Release Society 2024. PMID: 39032574


  10. Benet LZ, Sodhi JK. Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance? European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024. PMID: 38522769


  14. Liu W, Yu Z, Wang Z, Waubant EL, Zhai S, Benet LZ. Using an animal model to predict the effective human dose for oral multiple sclerosis drugs. Clinical and translational science 2022. PMID: 36419359


  15. Pachter JA, Dill KA, Sodhi JK, Benet LZ. Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance. Pharmacology & therapeutics 2022. PMID: 36075300


  16. Bocci G, Oprea TI, Benet LZ. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. "Anemia in Pregnancy," Chapter 74 in Iffy L. and Kaminetzky H. (editors): Textbook of Obstetrics and Perinatology. 1st edition 2022. PMID: 35199251


  17. Kameyama T, Sodhi J, Benet LZ. Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide A Useful Improvement in In Vitro-In Vivo Extrapolation (IVIVE) Predictability? "Anemia in Pregnancy," Chapter 74 in Iffy L. and Kaminetzky H. (editors): Textbook of Obstetrics and Perinatology. 1st edition 2022. PMID: 35086847


  18. Benet LZ, Sodhi JK. Can In Vitro In Vivo Extrapolation (IVIVE) Be Successful? Recognizing the Incorrect Clearance Assumptions. "Anemia in Pregnancy," Chapter 74 in Iffy L. and Kaminetzky H. (editors): Textbook of Obstetrics and Perinatology. 1st edition 2021. PMID: 34731496


  19. Liu S, Sodhi JK, Benet LZ. Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies. "Anemia in Pregnancy," Chapter 74 in Iffy L. and Kaminetzky H. (editors): Textbook of Obstetrics and Perinatology. 1st edition 2021. PMID: 34729703


  20. Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ. Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing. AAPS PharmSciTech 2021. PMID: 34410534


  22. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clinical pharmacology and therapeutics 2021. PMID: 33880760


  25. Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug testing and analysis 2021. PMID: 33742745


  27. Sodhi JK, Benet LZ. Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. Journal of medicinal chemistry 2021. PMID: 33765384


  28. Sodhi JK, Huang CH, Benet LZ. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clinical pharmacokinetics 2020. PMID: 32725383


  29. Sodhi JK, Liu S, Benet LZ. Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. Pharmaceutical research 2020. PMID: 32996065


  31. Di L, Artursson P, Avdeef A, Benet L, Houston B, Kansy M, Kerns E, Lennernäs H, Smith D, Sugano K. The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem 2020. PMID: 32743945


  34. Sodhi JK, Wang HJ, Benet LZ. Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Drug metabolism and disposition: the biological fate of chemicals 2020. PMID: 32305951


  38. Bocci G, Benet LZ, Oprea TI. Can BDDCS illuminate targets in drug design? Drug discovery today 2019. PMID: 31585170


  40. Bowman CM, Benet LZ. In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 31551322


  41. Surofchy DD, Frassetto LA, Benet LZ. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharmaceutical research 2019. PMID: 31485804


  42. Benet LZ, Bowman CM, Sodhi JK. How Transporters Have Changed Basic Pharmacokinetic Understanding. The AAPS journal 2019. PMID: 31482335


  43. Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 31201213


  45. Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. Journal of pharmacokinetics and pharmacodynamics 2019. PMID: 30911879


  46. Bowman CM, Benet LZ. In vitro-in vivo extrapolation and hepatic clearance dependent underprediction. Journal of pharmaceutical sciences 2019. PMID: 30817922


  47. Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. Characterization of fasiglifam-related liver toxicity in dogs. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 30765394


  48. Bowman CM, Okochi H, Benet LZ. The Presence of a Transporter-Induced Protein Binding Shift: A new Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 30674616


  49. Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E. Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clinical pharmacology and therapeutics 2019. PMID: 30652313


  50. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clinical pharmacology and therapeutics 2019. PMID: 30652304


  51. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. International journal for parasitology. Drugs and drug resistance 2018. PMID: 30503203


  52. Benet LZ, Bowman CM, Liu S, Sodhi JK. The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharmaceutical research 2018. PMID: 30349948


  53. Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox biology 2018. PMID: 30391827


  54. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine 2018. PMID: 30906930


  55. Bowman CM, Benet LZ. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2018. PMID: 30098391


  58. Chan R, Benet LZ. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Volume 162 of Issue 2. 2018. PMID: 29272540


  59. Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. A Drug-drug Interaction Between Cyclosporine and Nystatin. 2018. PMID: 29551534


  60. Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Volume 32 of Issue 5. 2018. PMID: 29315954


  62. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Volume 8 of Issue 1. Scientific Reports 2018. PMID: 29311658


  63. Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. Comparison of Measures of Adherence to HIV Preexposure Prophylaxis among Adolescent and Young Men Who Have Sex with Men in the United States. Volume 66 of Issue 2. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017. PMID: 29020194


  64. Benet LZ, Liu S, Wolfe AR. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clinical pharmacology and therapeutics 2017. PMID: 28762489


  65. Morrissey KM, Benet LZ, Ware JA. Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-ß-D-Glucuronide". Clinical and translational science 2017. PMID: 28664655


  66. Benet LZ, Wu HF. Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics. Volume 106 of Issue 9. 2017. PMID: 28502797


  67. Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. Volume 106 of Issue 9. 2017. PMID: 28385546


  68. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. Volume 106 of Issue 9. 2017. PMID: 28385543


  69. Chan R, Benet LZ. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Volume 30 of Issue 4. 2017. PMID: 28257576


  70. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS research and human retroviruses 2017. PMID: 28253024


  71. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Volume 34 of Issue 3. 2016. PMID: 28028768


  73. Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B. Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial. Volume 101 of Issue 3. 2016. PMID: 27727445


  74. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Volume 3 of Issue 11. 2016. PMID: 27658870


  76. Benet LZ. 2016 Remington Honor Medal Address: Science for the profession. Volume 56 of Issue 4. 2016. PMID: 27450136


  77. Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Volume 20 of Issue 6. 2016. PMID: 27155191


  78. Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and drugability. Volume 101. 2016. PMID: 27182629


  79. Burmeister Getz E, Carroll KJ, Jones B, Benet LZ. Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial. Volume 100 of Issue 3. 2016. PMID: 27037630


  84. Garrison KL, Sahin S, Benet LZ. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. Volume 104 of Issue 9. 2015. PMID: 26010239


  86. Zheng Y, Benet LZ, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Volume 32 of Issue 8. 2015. PMID: 25690341


  87. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Volume 15 of Issue 6. Clinical lymphoma, myeloma & leukemia 2015. PMID: 25776193


  89. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. Volume 16 of Issue 6. 2014. PMID: 25274610


  90. Hosey CM, Broccatelli F, Benet LZ. Predicting when biliary excretion of parent drug is a major route of elimination in humans. Volume 16 of Issue 5. 2014. PMID: 25004821


  92. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Volume 97 of Issue 6. 2014. PMID: 24389906


  93. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Volume 508 of Issue 7494. 2014. PMID: 24572354


  94. Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Volume 10 of Issue 11. 2013. PMID: 24044612


  95. Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Volume 10 of Issue 11. 2013. PMID: 24044638


  96. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Volume 34 of Issue 8. 2013. PMID: 24030928


  97. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Volume 10 of Issue 11. 2013. PMID: 23980906


  99. Horng H, Benet LZ. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Volume 26 of Issue 3. 2013. PMID: 23402341


  100. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Volume 30 of Issue 4. 2013. PMID: 23417511


  104. Budha NR, Benet LZ, Ware JA. Response to "Drug interactions produced by proton pump inhibitors: not simply a pH effect". Clinical pharmacology and therapeutics 2012. PMID: 23169432


  105. Estudante M, Morais JG, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Volume 65 of Issue 10. 2012. PMID: 23041352


  106. Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy? Volume 92 of Issue 2. 2012. PMID: 22739140


  108. Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Volume 29 of Issue 7. 2012. PMID: 22350803


  109. Broccatelli F, Cruciani G, Benet LZ, Oprea TI. BDDCS class prediction for new molecular entities. Volume 9 of Issue 3. 2012. PMID: 22224483


  110. Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Volume 64 of Issue 1. 2011. PMID: 22261306


  111. Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Volume 31 of Issue 9. 2011. PMID: 21923588


  112. Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Volume 39 of Issue 11. 2011. PMID: 21849516


  113. Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. Volume 13 of Issue 4. 2011. PMID: 21818695


  114. Rowland M, Benet LZ. Lead PK commentary: predicting human pharmacokinetics. Volume 100 of Issue 10. 2011. PMID: 21630278


  115. Terasaki T, Sugiyama Y, Benet LZ. Professor Akira Tsuji: scientist, educator, and leader. Volume 100 of Issue 9. 2011. PMID: 21630279


  118. Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Volume 28 of Issue 7. 2011. PMID: 21491148


  119. Park MS, Okochi H, Benet LZ. Is Ciprofloxacin a Substrate of P-glycoprotein? Volume 4 of Issue 1. 2011. PMID: 21572514


  120. Aarons L, Benet LZ. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. Volume 37 of Issue 6. 2010. PMID: 21069561


  121. Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. Volume 37 of Issue 6. 2010. PMID: 21113650


  122. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Volume 32 of Issue 1. 2010. PMID: 21075140


  123. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Volume 88 of Issue 4. 2010. PMID: 20703222


  125. . Membrane transporters in drug development. Volume 9 of Issue 3. 2010. PMID: 20190787


  126. Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B. Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation. Volume 32 of Issue 3. 2010. PMID: 20399990


  127. Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Volume 87 of Issue 4. 2010. PMID: 20090676


  128. Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Volume 38 of Issue 1. 2010. PMID: 19786506


  130. de Souza J, Benet LZ, Huang Y, Storpirtis S. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. Volume 98 of Issue 11. 2009. PMID: 19472342


  131. Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Volume 6 of Issue 6. 2009. PMID: 19874004


  133. Shugarts S, Benet LZ. The role of transporters in the pharmacokinetics of orally administered drugs. Volume 26 of Issue 9. 2009. PMID: 19568696


  135. Grover A, Benet LZ. Effects of drug transporters on volume of distribution. Volume 11 of Issue 2. 2009. PMID: 19399628


  136. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. Volume 50 of Issue 5. Journal of acquired immune deficiency syndromes (1999) 2009. PMID: 19408353


  139. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. Volume 2 of Issue 5. 2008. PMID: 19745507


  140. Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Volume 21 of Issue 10. 2008. PMID: 18693772


  141. Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Volume 25 of Issue 3. 2008. PMID: 18236138


  142. Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Volume 36 of Issue 4. 2008. PMID: 18187563


  143. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Volume 8 of Issue 2. 2007. PMID: 18093266


  145. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Volume 7 of Issue 12. 2007. PMID: 17949460


  146. Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. Volume 42 of Issue 6. 2007. PMID: 17511017


  147. Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Volume 81 of Issue 6. 2007. PMID: 17361125


  148. Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Volume 35 of Issue 5. 2007. PMID: 17303625


  149. Benet LZ. Review and critique of the Institute of Medicine report "the future of drug safety". Clinical pharmacology and therapeutics 2007. PMID: 17259941


  150. Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Volume 81 of Issue 2. 2006. PMID: 17192770


  151. Lam JL, Shugarts SB, Okochi H, Benet LZ. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. Volume 319 of Issue 2. 2006. PMID: 16905688


  154. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Volume 34 of Issue 7. 2006. PMID: 16581945


  156. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Volume 49 of Issue 12. Antimicrobial agents and chemotherapy 2005. PMID: 16304193


  157. Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Volume 18 of Issue 11. 2005. PMID: 16300382


  159. Chang JH, Benet LZ. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Volume 2 of Issue 5. 2005. PMID: 16196496


  160. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Volume 109 of Issue 1-2. 2005. PMID: 16085315


  161. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Volume 10 of Issue 4. 2005. PMID: 16109088


  162. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Volume 80 of Issue 1. 2005. PMID: 16003227


  163. Putnam WS, Woo JM, Huang Y, Benet LZ. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. Volume 45 of Issue 4. 2005. PMID: 15778422


  165. Benet L. Basic pharmacological interactions and how they may impact on one another. Volume 38 Suppl 1. Journal of acquired immune deficiency syndromes (1999) 2005. PMID: 15867606


  169. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Volume 26 of Issue 5. 2004. PMID: 15385839


  170. Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Volume 63 of Issue 2. 2004. PMID: 15390346


  171. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Volume 143 of Issue 3. 2004. PMID: 15339861


  172. Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Volume 32 of Issue 11. 2004. PMID: 15286055


  174. Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. International journal of pharmaceutics 2004. PMID: 15158963


  175. Frassetto LA, Benet LZ. Pharmacogenomics and transplantation: where are we? Volume 4 of Issue 6. 2004. PMID: 15147415


  176. Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Volume 4 of Issue 2. 2004. PMID: 15087483


  177. Lau YY, Wu CY, Okochi H, Benet LZ. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. Volume 308 of Issue 3. 2003. PMID: 14634033


  179. Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. Volume 308 of Issue 1. 2003. PMID: 14569063


  180. Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Current drug metabolism 2003. PMID: 14529371


  181. Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Volume 31 of Issue 6. 2003. PMID: 12756204


  182. Li C, Grillo MP, Benet LZ. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. Volume 305 of Issue 1. 2003. PMID: 12649376


  183. Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. Volume 305 of Issue 1. 2003. PMID: 12649383


  184. Li C, Grillo MP, Benet LZ. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Volume 187 of Issue 2. 2003. PMID: 12649042


  185. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Volume 18 of Issue 2. 2003. PMID: 15618725


  186. Hebert MF, Wacher VJ, Roberts JP, Benet LZ. Pharmacokinetics of cyclosporine pre- and post-liver transplantation. Volume 43 of Issue 1. 2003. PMID: 12520626


  187. Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. Journal of pharmaceutical sciences 2002. PMID: 12434407


  188. Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Volume 68 of Issue 12. 2002. PMID: 12494328


  189. Li C, Benet LZ, Grillo MP. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. Chemical research in toxicology 2002. PMID: 12437340


  190. Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clinical pharmacology and therapeutics 2002. PMID: 12426511


  191. Li C, Benet LZ, Grillo MP. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. Chemical research in toxicology 2002. PMID: 12387630


  192. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. Volume 302 of Issue 3. 2002. PMID: 12183671


  195. Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Volume 71 of Issue 3. 2002. PMID: 11907485


  196. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Volume 22 of Issue 3. 2002. PMID: 11891440


  197. Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. Volume 42 of Issue 3. 2002. PMID: 11865967


  198. Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. Volume 300 of Issue 3. 2002. PMID: 11861813


  199. Unger M, Jacobsen W, Holzgrabe U, Benet LZ. Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction. Volume 767 of Issue 2. 2002. PMID: 11885853


  200. Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharmaceutical research 2002. PMID: 11837697


  202. Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clinical pharmacokinetics 2002. PMID: 12190331


  203. Grillo MP, Benet LZ. Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro. Volume 30 of Issue 1. 2002. PMID: 11744612


  204. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clinical pharmacology and therapeutics 2001. PMID: 11719733


  205. Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Advanced drug delivery reviews 2001. PMID: 11576692


  206. Grillo MP, Chiellini G, Tonelli M, Benet LZ. Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats. Drug metabolism and disposition: the biological fate of chemicals 2001. PMID: 11502730


  208. Grillo MP, Benet LZ. Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat. Chemical research in toxicology 2001. PMID: 11511177


  209. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. British journal of pharmacology 2001. PMID: 11454661


  210. Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. Journal of medicinal chemistry 2001. PMID: 11384247


  211. Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Advanced drug delivery reviews 2001. PMID: 11259835


  212. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplantation proceedings 2001. PMID: 11266932


  213. Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L. Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2001. PMID: 11250452


  214. Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharmaceutical research 2001. PMID: 11336351


  216. Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clinical pharmacokinetics 2001. PMID: 11327196


  217. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clinical pharmacology and therapeutics 2001. PMID: 11180035


  218. Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ. Chiral bioequivalence: effect of absorption rate on racemic etodolac. Clinical pharmacokinetics 2000. PMID: 11192477


  219. Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug metabolism and disposition: the biological fate of chemicals 2000. PMID: 11038163


  220. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug metabolism and disposition: the biological fate of chemicals 2000. PMID: 11038166


  221. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. Journal of chromatography. B, Biomedical sciences and applications 2000. PMID: 11092585


  222. Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. The Journal of pharmacology and experimental therapeutics 2000. PMID: 10871329


  223. Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited. Therapeutic drug monitoring 2000. PMID: 10850403


  224. Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. British journal of pharmacology 2000. PMID: 10725273


  225. Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. British journal of pharmacology 2000. PMID: 10711346


  226. Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE. Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation 2000. PMID: 10653384


  227. Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug metabolism and disposition: the biological fate of chemicals 1999. PMID: 10570034


  228. Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. Journal of controlled release : official journal of the Controlled Release Society 1999. PMID: 10518631


  229. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. The Journal of pharmacology and experimental therapeutics 1999. PMID: 10490896


  230. Mizuma T, McDonagh AF, Lin ET, Benet LZ. Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin. British journal of clinical pharmacology 1999. PMID: 10383564


  231. Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. The Journal of pharmacology and experimental therapeutics 1999. PMID: 10215655


  232. Benet LZ. Relevance of pharmacokinetics in narrow therapeutic index drugs. Transplantation proceedings 1999. PMID: 10331032


  233. Benet LZ. Understanding bioequivalence testing. Transplantation proceedings 1999. PMID: 10330950


  235. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharmaceutical research 1999. PMID: 10227700


  238. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug metabolism and disposition: the biological fate of chemicals 1999. PMID: 9929499


  239. Salphati L, Benet LZ. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica; the fate of foreign compounds in biological systems 1999. PMID: 10199593


  240. Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA. Molecular and physical mechanisms of first-pass extraction. Drug metabolism and disposition: the biological fate of chemicals 1999. PMID: 9929497


  242. Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. Journal of chromatography. B, Biomedical sciences and applications 1998. PMID: 9892080


  243. Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. Journal of clinical pharmacology 1998. PMID: 11301566


  244. Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. Journal of pharmaceutical sciences 1998. PMID: 9811484


  245. Mizuma T, Benet LZ, Lin ET. High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide. Journal of chromatography. B, Biomedical sciences and applications 1998. PMID: 9832372


  250. Salphati L, Benet LZ. Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology 1998. PMID: 9654217


  251. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. The Journal of pharmacology and experimental therapeutics 1998. PMID: 9618413


  252. Zhang Y, Guo X, Lin ET, Benet LZ. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug metabolism and disposition: the biological fate of chemicals 1998. PMID: 9531525


  253. Mohri K, Okada K, Benet LZ. Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide. Drug metabolism and disposition: the biological fate of chemicals 1998. PMID: 9531520


  254. Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharmacology 1998. PMID: 9532615


  255. Qiu Y, Burlingame AL, Benet LZ. Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals 1998. PMID: 9492388


  256. Salphati L, Benet LZ. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochemical pharmacology 1998. PMID: 9514072


  258. Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. Journal of pharmacokinetics and biopharmaceutics 1997. PMID: 9697076


  259. Jang GR, Benet LZ. Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. Drug metabolism and disposition: the biological fate of chemicals 1997. PMID: 9321513


  260. Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clinical pharmacology and therapeutics 1997. PMID: 9333100


  261. Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clinical pharmacology and therapeutics 1997. PMID: 9246018


  262. Yuan R, Sumi M, Benet LZ. Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo. The Journal of pharmacology and experimental therapeutics 1997. PMID: 9190888


  263. Wu ST, Benet LZ, Lin ET. Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection. Journal of chromatography. B, Biomedical sciences and applications 1997. PMID: 9187394


  264. Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET. Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization. Journal of chromatography. B, Biomedical sciences and applications 1997. PMID: 9187392


  265. Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL. Evaluation of orally administered highly variable drugs and drug formulations. Pharmaceutical research 1996. PMID: 8956322


  266. Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. Journal of clinical pharmacology 1996. PMID: 8973990


  267. Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. British journal of clinical pharmacology 1996. PMID: 8904626


  268. Benet LZ. Morality play. Science (New York, N.Y.) 1996. PMID: 8815536


  269. Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochemical pharmacology 1996. PMID: 8765473


  271. Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ. Acute dose-dependent disposition studies of nicotinic acid in rats. Drug metabolism and disposition: the biological fate of chemicals 1996. PMID: 8818575


  273. Berg-Candolfi M, Candolfi E, Benet LZ. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica; the fate of foreign compounds in biological systems 1996. PMID: 9173679


  274. Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ. The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. Clinical pharmacology and therapeutics 1996. PMID: 8612388


  275. Jaeger W, Benet LZ, Bornheim LM. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica; the fate of foreign compounds in biological systems 1996. PMID: 8730919


  276. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clinical pharmacology and therapeutics 1996. PMID: 8653992


  277. Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical pharmacology and therapeutics 1995. PMID: 7586942


  278. Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. Journal of clinical pharmacology 1995. PMID: 8626883


  280. d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ. Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation. Journal of clinical pharmacology 1995. PMID: 8568014


  281. Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ. Stereoselective disposition of naproxen glucuronide in the rat. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 8654198


  282. Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 8565778


  283. Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ. Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 7493549


  284. Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs 1995. PMID: 8521756


  285. Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ. Stereoselective binding properties of naproxen glucuronide diastereomers to proteins. Journal of pharmacokinetics and biopharmaceutics 1995. PMID: 8882746


  286. Benet LZ, Goyan JE. Bioequivalence and narrow therapeutic index drugs. Pharmacotherapy 1995. PMID: 7479195


  288. Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clinical pharmacology and therapeutics 1995. PMID: 7628178


  289. Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharmaceutics & drug disposition 1995. PMID: 7548779


  292. Benet LZ, Zia-Amirhosseini P. Basic principles of pharmacokinetics. Toxicologic pathology 1995. PMID: 7569664


  293. Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ. Biliary excretion of furosemide glucuronide in rabbits. Biological & pharmaceutical bulletin 1995. PMID: 7550101


  294. Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ. Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 7628303


  295. Sekikawa H, Yagi N, Lin ET, Benet LZ. Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution. Biological & pharmaceutical bulletin 1995. PMID: 7735228


  297. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nature medicine 1995. PMID: 7584944


  299. Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ. Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction. Journal of chromatography. B, Biomedical applications 1994. PMID: 7866544


  300. Perotti BY, Prueksaritanont T, Benet LZ. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharmaceutical research 1994. PMID: 7524055


  301. Ojingwa JC, Spahn-Langguth H, Benet LZ. Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica; the fate of foreign compounds in biological systems 1994. PMID: 7975715


  302. Gustavson LE, Benet LZ. Menopause: pharmacodynamics and pharmacokinetics. Experimental gerontology 1994. PMID: 7925762


  303. Han C, Jung P, Sanders SW, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharmaceutics & drug disposition 1994. PMID: 8011969


  304. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of clinical pharmacology 1994. PMID: 8163710


  305. Ojingwa JC, Spahn-Langguth H, Benet LZ. Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. Journal of pharmacokinetics and biopharmaceutics 1994. PMID: 8027947


  306. Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ. Bioactivation by glucuronide-conjugate formation. Advances in pharmacology (San Diego, Calif.) 1994. PMID: 8068561


  307. Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Clinical pharmacology and therapeutics 1994. PMID: 8299313


  308. Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ. FK 506 metabolism in male and female rat liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 1994. PMID: 7512020


  309. Benet LZ. Pharmacokinetic profile of etodolac in special populations. European journal of rheumatology and inflammation 1994. PMID: 7744123


  310. Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. Journal of clinical pharmacology 1994. PMID: 8132853


  311. Benet LZ, Zech K. Pharmacokinetics--a relevant factor for the choice of a drug? Alimentary pharmacology & therapeutics 1994. PMID: 8180291


  313. Lee FW, Salmonson T, Benet LZ. Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies. Journal of pharmacokinetics and biopharmaceutics 1993. PMID: 8145130


  316. Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A. Drug metabolism and disposition: the biological fate of chemicals 1993. PMID: 8104135


  318. Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 1993. PMID: 8483897


  319. Spahn-Langguth H, Benet LZ. Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides. Pharmacology 1993. PMID: 8488171


  320. Lee FW, Hu J, Metzler CH, Benet LZ. Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report. Journal of pharmacokinetics and biopharmaceutics 1993. PMID: 8229678


  321. Benet LZ. New techniques in drug metabolism and clinical pharmacology/pharmacokinetics. American biotechnology laboratory 1993. PMID: 7763426


  322. Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H. In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. Chirality 1993. PMID: 8338721


  323. Benet LZ. Pharmacokinetics of sustained-release etodolac. Rheumatology international 1993. PMID: 8210922


  324. Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET. Predictability of the covalent binding of acidic drugs in man. Life sciences 1993. PMID: 8350674


  325. Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clinical pharmacology and therapeutics 1992. PMID: 1458768


  326. Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clinical pharmacology and therapeutics 1992. PMID: 1424418


  328. Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J. Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin. Anesthesiology 1992. PMID: 1416161


  329. Han C, Gumbleton M, Lau DT, Benet LZ. Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites. Journal of chromatography 1992. PMID: 1429971


  330. Prueksaritanont T, Hoener BA, Benet LZ. Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions. Drug metabolism and disposition: the biological fate of chemicals 1992. PMID: 1356733


  331. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of pharmaceutical sciences 1992. PMID: 1355792


  332. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Pharmaceutical research 1992. PMID: 1409369


  333. Lau DT, Benet LZ. Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation. Biochemical pharmacology 1992. PMID: 1599510


  334. Prueksaritanont T, Koike M, Hoener BA, Benet LZ. Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids. Biochemical pharmacology 1992. PMID: 1596287


  335. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clinical pharmacology and therapeutics 1992. PMID: 1563216


  336. Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement. Pharmaceutical research 1992. PMID: 1614960


  337. Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharmaceutical research 1992. PMID: 1553339


  340. Volland C, Sun H, Dammeyer J, Benet LZ. Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein. Drug metabolism and disposition: the biological fate of chemicals 1991. PMID: 1687014


  341. Hale VG, Aizawa K, Sheiner LB, Benet LZ. Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes. Journal of pharmacokinetics and biopharmaceutics 1991. PMID: 1783993


  342. Kikkoji T, Gumbleton M, Higo N, Guy RH, Benet LZ. Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro. Pharmaceutical research 1991. PMID: 1796039


  343. Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug metabolism and disposition: the biological fate of chemicals 1991. PMID: 1686227


  344. Hammarlund-Udenaes M, Benet LZ. Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations. Biopharmaceutics & drug disposition 1991. PMID: 1932610


  346. Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ. Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations. Pharmaceutical research 1991. PMID: 1905809


  347. Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET. Stereoselective disposition of ketoprofen in rats. Drug metabolism and disposition: the biological fate of chemicals 1991. PMID: 1680643


  349. Lau DT, Gumbleton M, Labisch C, Benet LZ. Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat. Biopharmaceutics & drug disposition 1991. PMID: 1905575


  350. Benet LZ. Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist. DICP : the annals of pharmacotherapy 1991. PMID: 1926916


  351. Gumbleton M, Benet LZ. Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers. British journal of clinical pharmacology 1991. PMID: 1904752


  352. Volland C, Benet LZ. In vitro enantioselective glucuronidation of fenoprofen. Pharmacology 1991. PMID: 1775510


  353. Hale VG, Benet LZ. Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver. Drug metabolism and disposition: the biological fate of chemicals 1991. PMID: 1673428


  354. Benet LZ. Safety and pharmacokinetics: colloidal bismuth subcitrate. Scandinavian journal of gastroenterology. Supplement 1991. PMID: 1957122


  355. Volland C, Sun H, Benet LZ. Stereoselective analysis of fenoprofen and its metabolites. Journal of chromatography 1990. PMID: 2094699


  356. Lee FW, Salmonson T, Metzler CH, Benet LZ. Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs. The Journal of pharmacology and experimental therapeutics 1990. PMID: 2124621


  357. Smith PC, Benet LZ, McDonagh AF. Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism. Drug metabolism and disposition: the biological fate of chemicals 1990. PMID: 1981713


  358. Skelley JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A. Report of the workshop on in vitro and in vivo testing and correlation for oral controlled/modified-release dosage forms. Journal of pharmaceutical sciences 1990. PMID: 1980308


  359. Manfro RC, Pohanka E, Tomlanovich SJ, Benet LZ, Salvatierra O, Garovoy MR. Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up. Transplantation proceedings 1990. PMID: 2389461


  360. Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. Journal of clinical pharmacology 1990. PMID: 2391396


  362. Nakashima E, Rigod JF, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses. Clinical pharmacology and therapeutics 1990. PMID: 2111749


  363. Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ. Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene. Biopharmaceutics & drug disposition 1990. PMID: 2328310


  364. Hamamoto K, Iwamoto HS, Roman CM, Benet LZ, Rudolph AM. Fetal uptake of intraamniotic digoxin in sheep. Pediatric research 1990. PMID: 2320396


  365. Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Biochemical pharmacology 1990. PMID: 2310420


  366. Wang LH, Rudolph AM, Benet LZ. Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods. Developmental pharmacology and therapeutics 1990. PMID: 2364855


  367. Smith PC, McDonagh AF, Benet LZ. Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig. The Journal of pharmacology and experimental therapeutics 1990. PMID: 2299592


  368. Gupta SK, Benet LZ. High-fat meals increase the clearance of cyclosporine. Pharmaceutical research 1990. PMID: 2300535


  369. Munafo A, McDonagh AF, Smith PC, Benet LZ. Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro. Pharmaceutical research 1990. PMID: 2300531


  370. Steffe EM, King JH, Inciardi JF, Flynn NF, Goldstein E, Tonjes TS, Benet LZ. The effect of acetaminophen on zidovudine metabolism in HIV-infected patients. Journal of acquired immune deficiency syndromes 1990. PMID: 2352121


  371. Nakashima E, Benet LZ. An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment. Journal of pharmacokinetics and biopharmaceutics 1989. PMID: 2635739


  372. Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ. Pharmacokinetics of nicotinic acid-salicylic acid interaction. Clinical pharmacology and therapeutics 1989. PMID: 2598568


  373. Gupta SK, Benet LZ. Absorption kinetics of cyclosporine in healthy volunteers. Biopharmaceutics & drug disposition 1989. PMID: 2611359


  374. Watari N, Benet LZ. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. Journal of pharmacokinetics and biopharmaceutics 1989. PMID: 2614687


  376. Bois FY, Tozer TN, Zeise L, Benet LZ. Application of clearance concepts to the assessment of exposure to lead in drinking water. American journal of public health 1989. PMID: 2735466


  377. Iwakawa S, Suganuma T, Lee SF, Spahn H, Benet LZ, Lin ET. Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man. Drug metabolism and disposition: the biological fate of chemicals 1989. PMID: 2571482


  378. Bois FY, Tozer TN, Benet LZ, Zeise L. Lead exposure in children vs adults. American journal of public health 1989. PMID: 2735489


  379. Koshida R, Nakashima E, Taniguchi N, Tsuji A, Benet LZ, Ichimura F. Prediction of the distribution volumes of cefazolin and tobramycin in obese children based on physiological pharmacokinetic concepts. Pharmaceutical research 1989. PMID: 2762224


  380. Spahn H, Spahn I, Benet LZ. Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study. Clinical pharmacology and therapeutics 1989. PMID: 2721105


  381. Gloff CA, Benet LZ. Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats. Journal of pharmacokinetics and biopharmaceutics 1989. PMID: 2795454


  382. Manfro RC, Pohanka E, Tomlanovich S, Benet LZ, Garovoy MR. Cyclosporin A and prednisolone: an additive inhibitory effect of cell proliferation and interleukin-2 production. Transplantation proceedings 1989. PMID: 2523586


  384. Hammarlund-Udenaes M, Benet LZ. Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update. Journal of pharmacokinetics and biopharmaceutics 1989. PMID: 2654356


  386. Spahn H, Spahn I, Pflugmann G, Mutschler E, Benet LZ. Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component. Journal of chromatography 1988. PMID: 3235564


  387. Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH. Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing. Biopharmaceutics & drug disposition 1988. PMID: 3147725


  388. Nakashima E, Benet LZ. General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment. Journal of pharmacokinetics and biopharmaceutics 1988. PMID: 3199315


  390. Hyneck ML, Smith PC, Munafo A, McDonagh AF, Benet LZ. Disposition and irreversible plasma protein binding of tolmetin in humans. Clinical pharmacology and therapeutics 1988. PMID: 3390998


  391. Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics 1988. PMID: 3378388


  393. Hyneck ML, Munafo A, Benet LZ. Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide. Drug metabolism and disposition: the biological fate of chemicals 1988. PMID: 2898354


  396. Noonan PK, Benet LZ. Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration. Clinical pharmacology and therapeutics 1987. PMID: 3113806


  397. Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharmaceutical research 1987. PMID: 3508542


  398. Nakashima E, Noonan PK, Benet LZ. Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin. Journal of pharmacokinetics and biopharmaceutics 1987. PMID: 3119815


  399. Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N. Pharmacokinetics and excretion of unique beta-adrenergic agonists. Pharmacology 1987. PMID: 2884679


  401. Benet LZ. AAPS and pharmaceutical research. Pharmaceutical research 1986. PMID: 24271580


  402. Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ. Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function. Clinical pharmacology and therapeutics 1986. PMID: 3731685


  403. Smith PC, Benet LZ. Characterization of the isomeric esters of zomepirac glucuronide by proton NMR. Drug metabolism and disposition: the biological fate of chemicals 1986. PMID: 2874000


  404. Varughese A, Brater DC, Benet LZ, Lee CS. Ethambutol kinetics in patients with impaired renal function. The American review of respiratory disease 1986. PMID: 3729159


  405. Wang LH, Rudolph AM, Benet LZ. Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit. The Journal of pharmacology and experimental therapeutics 1986. PMID: 3723398


  407. Legler UF, Benet LZ. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives. Clinical pharmacology and therapeutics 1986. PMID: 3956058


  408. Smith PC, McDonagh AF, Benet LZ. Irreversible binding of zomepirac to plasma protein in vitro and in vivo. The Journal of clinical investigation 1986. PMID: 3949982


  409. Noonan PK, Benet LZ. The bioavailability of oral nitroglycerin. Journal of pharmaceutical sciences 1986. PMID: 3084757


  410. Sörgel F, Ettinger B, Benet LZ. Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis. Journal of pharmaceutical sciences 1986. PMID: 3958920


  411. Gustavson LE, Legler UF, Benet LZ. Impairment of prednisolone disposition in women taking oral contraceptives or conjugated estrogens. The Journal of clinical endocrinology and metabolism 1986. PMID: 2999180


  412. Legler UF, Benet LZ. The effect of prednisone and hydrocortisone on the plasma protein binding of prednisolone in man. European journal of clinical pharmacology 1986. PMID: 3709632


  413. Gustavson LE, Benet LZ. The macromolecular binding of prednisone in plasma of healthy volunteers including pregnant women and oral contraceptive users. Journal of pharmacokinetics and biopharmaceutics 1985. PMID: 3834071


  414. Wang LH, Rudolph AM, Benet LZ. Distribution and fate of acetaminophen conjugates in fetal lambs in utero. The Journal of pharmacology and experimental therapeutics 1985. PMID: 4057072


  415. Sheiner LB, Benet LZ. Premarketing observational studies of population pharmacokinetics of new drugs. Clinical pharmacology and therapeutics 1985. PMID: 3931953


  416. Sörgel F, Ettinger B, Benet LZ. The true composition of kidney stones passed during triamterene therapy. The Journal of urology 1985. PMID: 4057369


  417. Benet LZ. Mean residence time in the body versus mean residence time in the central compartment. Journal of pharmacokinetics and biopharmaceutics 1985. PMID: 3834069


  418. Smith PC, Langendijk PN, Bosso JA, Benet LZ. Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac. Clinical pharmacology and therapeutics 1985. PMID: 3874742


  419. Ferraiolo BL, Benet LZ. Peptides and proteins as drugs. Pharmaceutical research 1985. PMID: 24272804


  420. Noonan PK, Williams RL, Benet LZ. Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers. Journal of pharmacokinetics and biopharmaceutics 1985. PMID: 3932639


  421. Benet LZ. Pharmacokinetics and metabolism of bepridil. The American journal of cardiology 1985. PMID: 3872057


  422. Tsang SY, Garovoy MR, Benet LZ. Immunosuppressive activity of prednisone and prednisolone and their metabolic interconversion in the mixed lymphocyte reaction. International journal of immunopharmacology 1985. PMID: 2931388


  423. Noonan PK, Benet LZ. Incomplete and delayed bioavailability of sublingual nitroglycerin. The American journal of cardiology 1985. PMID: 3917598


  424. Wang LH, Rudolph AM, Benet LZ. Pharmacokinetics of drugs and metabolites in the maternal-placental-fetal unit: general principles. NIDA research monograph 1985. PMID: 3932864


  425. Smith PC, Hasegawa J, Langendijk PN, Benet LZ. Stability of acyl glucuronides in blood, plasma, and urine: studies with zomepirac. Drug metabolism and disposition: the biological fate of chemicals 1985. PMID: 2858367


  426. Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. Journal of pharmacokinetics and biopharmaceutics 1984. PMID: 6533293


  427. Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. The American journal of medicine 1984. PMID: 6496560


  428. Noonan PK, Kanfer I, Riegelman S, Benet LZ. Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection. Journal of pharmaceutical sciences 1984. PMID: 6432997


  429. Sörgel F, Lin ET, Hasegawa J, Benet LZ. Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine. Journal of pharmaceutical sciences 1984. PMID: 6737274


  430. Langendijk PN, Smith PC, Hasegawa J, Benet LZ. Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. Journal of chromatography 1984. PMID: 6610684


  432. Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies. Pharmacology 1984. PMID: 6728896


  433. Benet LZ. Pharmacokinetic parameters: which are necessary to define a drug substance? European journal of respiratory diseases. Supplement 1984. PMID: 6586486


  434. Meister W, Benowitz NL, Benet LZ. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology 1984. PMID: 6709691


  435. Spitzer W, Sörgel F, Krakau I, Tang D, Benet LZ, Lang E. [Heart failure and diuretics. Pharmacokinetics with furosemide]. MMW, Munchener medizinische Wochenschrift 1983. PMID: 6417494


  436. Baughman RA, Sorgel F, Mico BA, Benet LZ. Dose-dependent bioavailability of prazosin in beagle dogs. Journal of cardiovascular pharmacology 1983. PMID: 6193359


  437. Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J. Oral bioavailability and intravenous pharmacokinetics of amrinone in humans. Journal of pharmaceutical sciences 1983. PMID: 6886991


  439. Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG. Furosemide assays and disposition in healthy volunteers and renal transplant patients. Federation proceedings 1983. PMID: 6339277


  440. Baughman RA, Mico BA, Benet LZ. The bioavailability and disposition of tiodazosin levulinate in beagle dogs with a comparison to prazosin hydrochloride. Drug metabolism and disposition: the biological fate of chemicals 1983. PMID: 6133719


  441. Smith DE, Benet LZ. Biotransformation of furosemide in kidney transplant patients. European journal of clinical pharmacology 1983. PMID: 6350024


  442. Smith DE, Benet LZ. Plasma protein binding of furosemide in kidney transplant patients. Journal of pharmacokinetics and biopharmaceutics 1982. PMID: 6763626


  443. Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM. Endogenous and exogenous glucocorticoids in cushingoid patients. Drug intelligence & clinical pharmacy 1982. PMID: 6756849


  444. O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ. Disposition of zomepirac sodium in man. Journal of clinical pharmacology 1982. PMID: 7174855


  445. Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ. Pharmacokinetics of triamterene and its metabolite in man. Journal of pharmacokinetics and biopharmaceutics 1982. PMID: 7166735


  446. Legler UF, Frey FJ, Benet LZ. Prednisolone clearance at steady state in man. The Journal of clinical endocrinology and metabolism 1982. PMID: 7107818


  447. Hasegawa J, Smith PC, Benet LZ. Apparent intramolecular acyl migration of zomepirac glucuronide. Drug metabolism and disposition: the biological fate of chemicals 1982. PMID: 6128195


  448. Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ. Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography. Journal of chromatography 1982. PMID: 6213630


  449. Mico BA, Baughman RA, Benet LZ. Determination of tiodazosin in plasma and whole blood by high-performance liquid chromatography. Journal of chromatography 1982. PMID: 7107763


  450. Frey BM, Frey FJ, Holford NH, Lozada F, Benet LZ. Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction. Transplantation 1982. PMID: 6213074


  451. Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. Journal of pharmaceutical sciences 1982. PMID: 7097499


  452. Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. Journal of clinical pharmacology 1982. PMID: 7061724


  453. Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ. Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. European journal of clinical pharmacology 1982. PMID: 6751835


  454. Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. Journal of clinical pharmacology 1981. PMID: 7037867


  455. Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ. Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone. The Journal of clinical endocrinology and metabolism 1981. PMID: 7026594


  456. Mamelok RD, Macrae DR, Benet LZ, Prusiner SB. Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica. Journal of neurochemistry 1981. PMID: 6115891


  457. Gustafson JH, Benet LZ. Saturable kinetics of intravenous chlorothiazide in the rhesus monkey. Journal of pharmacokinetics and biopharmaceutics 1981. PMID: 7310644


  458. Smith DE, Gambertoglio JG, Vincenti F, Benet LZ. Furosemide kinetics and dynamics after kidney transplant. Clinical pharmacology and therapeutics 1981. PMID: 7016396


  459. Sheiner LB, Benet LZ, Pagliaro LA. A standard approach to compiling clinical pharmacokinetic data. Journal of pharmacokinetics and biopharmaceutics 1981. PMID: 7014827


  460. Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys-intravenous bolus studies. Pharmacology 1981. PMID: 7312942


  461. Frey FJ, Amend WJ, Lozada F, Frey BM, Holford NH, Benet LZ. Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients. European journal of clinical pharmacology 1981. PMID: 7032949


  463. Frey FJ, Frey BM, Greither A, Benet LZ. Prednisolone clearance at steady state in dogs. The Journal of pharmacology and experimental therapeutics 1980. PMID: 7441495


  464. Brater DC, Kaojarern S, Benet LZ, Lin ET, Lockwood T, Morris RC, McSherry EJ, Melmon KL. Renal excretion of pseudoephedrine. Clinical pharmacology and therapeutics 1980. PMID: 7438686


  465. Lin ET, Baughman RA, Benet LZ. High-performance liquid chromatographic determination of prazosin in human plasma, whole blood and urine. Journal of chromatography 1980. PMID: 7419656


  466. Smith DE, Lin ET, Benet LZ. Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. Drug metabolism and disposition: the biological fate of chemicals 1980. PMID: 6107232


  467. Lee CS, Brater DC, Gambertoglio JG, Benet LZ. Disposition kinetics of ethambutol in man. Journal of pharmacokinetics and biopharmaceutics 1980. PMID: 7431225


  468. Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL. Altered prazosin pharmacokinetics in congestive heart failure. European journal of clinical pharmacology 1980. PMID: 7398734


  469. Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ. Preliminary evaluation of furosemide-probenecid interaction in humans. Journal of pharmaceutical sciences 1980. PMID: 7381747


  470. Lee CS, Marbury TC, Benet LZ. Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol. Journal of pharmacokinetics and biopharmaceutics 1980. PMID: 7381692


  471. Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH. Inhibition by indomethacin of the glycemic response to arginine in man. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1980. PMID: 6987677


  472. Gambertoglio JG, Amend WJ, Benet LZ. Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review. Journal of pharmacokinetics and biopharmaceutics 1980. PMID: 6991663


  473. Williams RL, Benet LZ. Drug pharmacokinetics in cardiac and hepatic disease. Annual review of pharmacology and toxicology 1980. PMID: 6992701


  474. Till AE, Benet LZ. Renal excretion of pseudoephedrine in the rat. The Journal of pharmacology and experimental therapeutics 1979. PMID: 41938


  475. Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ. Cefamandole kinetics in uremic patients undergoing hemodialysis. Clinical pharmacology and therapeutics 1979. PMID: 498702


  476. Ding TL, Benet LZ. Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug metabolism and disposition: the biological fate of chemicals 1979. PMID: 43222


  477. Frey FJ, Frey BM, Benet LZ. Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma. Clinical chemistry 1979. PMID: 498504


  478. Arnold SB, Williams RL, Ports TA, Baughman RA, Benet LZ, Parmley WW, Chatterjee K. Attenuation of prazosin effect on cardiac output in chronic heart failure. Annals of internal medicine 1979. PMID: 475164


  479. Benet LZ, Galeazzi RL. Noncompartmental determination of the steady-state volume of distribution. Journal of pharmaceutical sciences 1979. PMID: 480170


  481. Lin ET, Smith DE, Benet LZ, Hoener BA. High-performance liquid chromatographic assays for furosemide in plasma and urine. Journal of chromatography 1979. PMID: 541387


  482. Smith DE, Brater DC, Lin ET, Benet LZ. Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation. Journal of pharmacokinetics and biopharmaceutics 1979. PMID: 480148


  483. Benet LZ. Pharmacokinetics/pharmacodynamics of furosemide in man: a review. Journal of pharmacokinetics and biopharmaceutics 1979. PMID: 458552


  484. Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K. Pharmacokinetics of furosemide in patients with congestive heart failure. Pharmacology 1979. PMID: 523503


  485. Till AE, Benet LZ. Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique. Pharmacology 1979. PMID: 493335


  487. Benet LZ. Effect of route of administration and distribution on drug action. Journal of pharmacokinetics and biopharmaceutics 1978. PMID: 731418


  488. Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. Anesthesiology 1978. PMID: 736287


  489. Lee CS, Benet LZ. Micro and macro GLC determination of ethambutol in biological fluids. Journal of pharmaceutical sciences 1978. PMID: 641750


  490. Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. Journal of pharmacokinetics and biopharmaceutics 1978. PMID: 671221


  491. Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ. Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis. Journal of clinical pharmacology 1978. PMID: 624775


  492. Barnett G, Lockwood T, Arancibia A, Benet LZ. Ascorbate stimulation of salicylate absorption in isolated rat intestine. Journal of pharmaceutical sciences 1978. PMID: 621642


  494. García CR, Siqueiros A, Benet LZ. Oral controlled release preparations. Pharmaceutica acta Helvetiae 1978. PMID: 360228


  495. Ding TL, Lin ET, Benet LZ. The reversible biotransformation of N-acetylprocainamide in the rhesus monkey. Arzneimittel-Forschung 1978. PMID: 416831


  496. Lee CS, Gambertoglio JG, Brater DC, Benet LZ. Kinetics of oral ethambutol in the normal subject. Clinical pharmacology and therapeutics 1977. PMID: 410579


  497. Benet LZ. Obligations of a major professor to a graduate student. American Journal of Pharmaceutical Education 1977. PMID: 10273029


  498. Lin ET, Brater DC, Benet LZ. Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urine. Journal of chromatography 1977. PMID: 914918


  499. Miller RD, Matteo RS, Benet LZ, Sohn YJ. The pharmacokinetics of d-tubocurarine in man with and without renal failure. The Journal of pharmacology and experimental therapeutics 1977. PMID: 195035


  500. Ronfeld RA, Benet LZ. Interpretation of plasma concentration-time curves after oral dosing. Journal of pharmaceutical sciences 1977. PMID: 839412


  501. Lee CS, Benet LZ. Gas-liquid chromatographic determination of ethambutol in plasma and urine of man and monkey. Journal of chromatography 1976. PMID: 825525


  502. Galeazzi RL, Benet LZ, Sheiner LB. Relationship between the pharmacokinetics and pharmacodynamics of procainamide. Clinical pharmacology and therapeutics 1976. PMID: 954350


  503. Galeazzi RL, Benet LZ. Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems. Journal of pharmacokinetics and biopharmaceutics 1976. PMID: 1271239


  504. Gustafson JH, Schoenwald RD, Benet LZ. Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities. Journal of pharmaceutical sciences 1976. PMID: 1255456


  505. Galeazzi RL, Sheiner LB, Lockwood T, Benet LZ. The renal elimination of procainamide. Clinical pharmacology and therapeutics 1976. PMID: 1171


  507. Orr JM, Benet LZ. The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies. The American journal of digestive diseases 1975. PMID: 1163521


  508. Ronfeld RA, Benet LZ. Dose dependent kinetics of carbamazepine in the monkey. Research communications in chemical pathology and pharmacology 1975. PMID: 1162177


  509. Till AE, Benet LZ, Kwan KC. An integrated approach to the pharmacokinetic analysis of drug absorption. Journal of pharmacokinetics and biopharmaceutics 1974. PMID: 4461782


  510. Gustafson JH, Benet LZ. Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. The Journal of pharmacy and pharmacology 1974. PMID: 4156858


  511. Nayak RK, Benet LZ. Use of the unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs. Journal of pharmacokinetics and biopharmaceutics 1974. PMID: 4452944


  512. Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. Journal of pharmacokinetics and biopharmaceutics 1973. PMID: 4764426


  513. Wolfe DL, Forland SC, Benet LZ. Drug transfer across intact rat intestinal mucosa following surgical removal of serosa and muscularis externa. Journal of pharmaceutical sciences 1973. PMID: 4686389


  514. Nelson JA, Moss AA, Goldberg HI, Benet LZ, Amberg J. Gastrointestinal absorption of iopanoic acid. Investigative radiology 1973. PMID: 4685376


  515. Nelson JA, Benet LZ, Goldberg HI. Absorption of iodipamide from the biliary system of the rabbit. The Journal of pharmacy and pharmacology 1972. PMID: 4146535


  517. Nayak RK, Benet LZ. Drug transfer across rat intestinal musculature after edetic acid treatment. Journal of pharmaceutical sciences 1971. PMID: 5001965


  518. Benet LZ, Turi JS. Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis. Journal of pharmaceutical sciences 1971. PMID: 5129385


  519. Benet LZ, Orr JM, Turner RH, Webb HS. Effect of buffer constituents and time on drug transfer across in vitro rat intestine. Journal of pharmaceutical sciences 1971. PMID: 5572446


  520. Turner RH, Mehta CS, Benet LZ. Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies. Journal of pharmaceutical sciences 1970. PMID: 5446410


  521. Rowland M, Benet LZ, Riegelman S. Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics. Journal of pharmaceutical sciences 1970. PMID: 5416180


  522. Kesselring UW, Benet LZ. Determination of a protonation scheme for isochlortetracycline using nuclear magnetic resonance. Analytical chemistry 1969. PMID: 5811585


  523. Benet LZ, Ronfeld RA. Volume terms in pharmacokinetics. Journal of pharmaceutical sciences 1969. PMID: 5796463


  524. Benet LZ, Goyan JE. Potentiometric determination of dissociation constants. Journal of pharmaceutical sciences 1967. PMID: 5340617


  525. Benet LZ, Goyan JE. Thermodynamics of chelation by tetracyclines. Journal of pharmaceutical sciences 1966. PMID: 4961420


  526. Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN. Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. Journal of pharmaceutical sciences 1966. PMID: 5918653


  527. Benet LZ, Goyan JE. Nonlogarithmic titration curves for the determination of dissociation constants and purity. Journal of pharmaceutical sciences 1965. PMID: 4956613


  528. Benet LZ, Goyan JE. Determination of the stability constants of tetracycline complexes. Journal of pharmaceutical sciences 1965. PMID: 5862536