Kathy Giacomini, PhD

Honors and Awards
  • Scheele Award, Swedish Academy of Pharmaceutical Scientists, 2011
  • Therapeutic Frontiers Lecture Award, Therapeutic Frontiers Lecture Award, 2010
  • Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics, 2009
  • Outstanding Mentor Award, Postdoctoral Scholars Association, University of California, San Francisco, 2009
  • Invitation Fellowship Program for Research in Japan, Japan Society for the Promotion of Science, 2008
  • International Woman Scientist Award, Academy of Pharmaceutical Sciences and Technology, Japan, 2007
  • Research Achievement Award, Pharmaceutical Sciences World Congress, 2007
  • Distinguished Scientist Award in Drug Metabolism, American Association of Pharmaceutical Scientists, 2006
  • Elected Member, Institute of Medicine of the National Academy of Sciences, 2006
  • Paul Dawson Biotechnology Award, American Association of Colleges of Pharmacy, 2005
  • Distinguished Gerhard Levy Lectureship, State University of New York at Buffalo, 2002
  • Distinguished Bill Abram's Lectureship, U.S. Food and Drug Administration, 2002
  • Honored Celebrating Women Faculty, University of California, San Francisco, 2002
  • Guttman Lecturer, University of Kentucky, 2000
  • Scientist of the Year, International Pharmaceutical Federation (FIP), 1999
  • Recognition Award for Distinguished Achievement of a Filipino at UCSF, University of California, San Francisco, 1999
  • Chancellor's Award for the Advancement of Women, University of California, San Francisco, 1997
  • Martin Luther King, Jr. Award for the Advancement of Minorities, University of California, San Francisco, 1994
  • Fogarty International Fellowship, National Institutes of Health, 1992
  • Leon Goldberg Young Investigator Award, American Society for Clinical Pharmacology and Therapeutics, 1990
  • Distinguished Teaching Award, University of California, San Francisco, Academic Senate, 1985
  • UCSF Nominee for Recognition Award for Young Scholar, American Association of University Women, 1984
  • Long Foundation Award for Excellence in Teaching, School of Pharmacy, University of California, San Francisco, 1983
Websites
Publications

  1. Brackman DJ, Giacomini KM. Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response. Volume 103 of Issue 2. 2017. PMID: 29023674


  2. Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for ABCG2. Volume 27 of Issue 11. 2017. PMID: 28858993


  3. Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Volume 102 of Issue 6. 2017. PMID: 28795399


  4. Hsueh CH, Hsu V, Zhao P, Zhang L, Giacomini KM, Huang SM. PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters. Volume 103 of Issue 3. 2017. PMID: 28738449


  5. Stecula A, Schlessinger A, Giacomini KM, Sali A. Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. Volume 56 of Issue 27. 2017. PMID: 28661652


  6. Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM. Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. Volume 57 of Issue 6. 2017. PMID: 28562037


  7. Liang X, Giacomini KM. Transporters Involved in Metformin Pharmacokinetics and Treatment Response. Volume 106 of Issue 9. 2017. PMID: 28495567


  8. Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. The Effect of Uremic Solutes on the Organic Cation Transporter 2. Volume 106 of Issue 9. 2017. PMID: 28483424


  9. Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM. Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Volume 60 of Issue 7. 2017. PMID: 28230985


  10. Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimcáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkác I, Stricker BH, Palmer C, 't Hart LM, Giacomini KM, Pearson ER. Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis. Volume 101 of Issue 6. 2017. PMID: 27859023


  11. Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N. Genomic Characterization of Metformin Hepatic Response. Volume 12 of Issue 11. 2016. PMID: 27902686


  12. Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Volume 16 of Issue 1. 2016. PMID: 27885282


  13. Giacomini KM. The use of drug transporters as therapeutic targets. Volume 14 of Issue 11. 2016. PMID: 27930637


  14. Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM. A Molecular Basis for Innovation in Drug Excipients. Volume 101 of Issue 3. 2016. PMID: 27557422


  15. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Volume 100 of Issue 5. 2016. PMID: 27415606


  16. Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Volume 100 of Issue 5. 2016. PMID: 27447836


  17. Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Volume 26 of Issue 20. 2016. PMID: 27624080


  18. Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. Volume 13 of Issue 9. 2016. PMID: 27467266


  19. Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Volume 48 of Issue 9. 2016. PMID: 27500523


  20. Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Volume 100 of Issue 5. 2016. PMID: 27256705


  21. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Volume 43 of Issue 7. 2016. PMID: 27044383


  22. Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Volume 7. 2016. PMID: 27378919


  23. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Volume 55 of Issue 6. 2016. PMID: 26597253


  24. Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T. A research roadmap for next-generation sequencing informatics. Volume 8 of Issue 335. Science translational medicine 2016. PMID: 27099173


  25. Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Volume 26 of Issue 11. 2016. PMID: 27106710


  26. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Volume 55 of Issue 4. 2016. PMID: 26507723


  27. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Volume 17 of Issue 2. 2016. PMID: 26856248


  28. Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Volume 44 of Issue 3. 2015. PMID: 26700958


  29. Altman RB, Khuri N, Salit M, Giacomini KM. Unmet needs: Research helps regulators do their jobs. Volume 7 of Issue 315. Science translational medicine 2015. PMID: 26606966


  30. Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Volume 12 of Issue 12. 2015. PMID: 26528626


  31. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Volume 43 of Issue 3. 2015. PMID: 26338179


  32. Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Prediction and validation of enzyme and transporter off-targets for metformin. Volume 42 of Issue 5. 2015. PMID: 26335661


  33. Lin L, Yee SW, Kim RB, Giacomini KM. SLC transporters as therapeutic targets: emerging opportunities. Volume 14 of Issue 8. 2015. PMID: 26111766


  34. Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Volume 88 of Issue 1. 2015. PMID: 25920679


  35. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Volume 97 of Issue 5. 2015. PMID: 25676789


  36. DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Villablanca JG, Marachelian A, Matthay KK. Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma. Volume 21 of Issue 12. 2015. PMID: 25695691


  37. Dahlin A, Wittwer M, de la Cruz M, Woo JM, Bam R, Scharen-Guivel V, Flaherty J, Ray AS, Cihlar T, Gupta SK, Giacomini KM. A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome. Volume 25 of Issue 2. 2015. PMID: 25485598


  38. Chen L, Yee SW, Giacomini KM. OCT1 in hepatic steatosis and thiamine disposition. Volume 14 of Issue 3. 2015. PMID: 25590948


  39. Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Genome-wide discovery of drug-dependent human liver regulatory elements. Volume 10 of Issue 10. 2014. PMID: 25275310


  40. Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC. Metformin pharmacogenomics: current status and future directions. Volume 63 of Issue 8. 2014. PMID: 25060887


  41. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Volume 111 of Issue 27. Proceedings of the National Academy of Sciences of the United States of America 2014. PMID: 24961373


  42. Goswami S, Gong L, Giacomini K, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for SLC22A1. Volume 24 of Issue 6. 2014. PMID: 24681965


  43. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Volume 96 of Issue 3. 2014. PMID: 24853734


  44. Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype. Volume 95 of Issue 6. 2014. PMID: 24598717


  45. Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM. Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations. Volume 53 of Issue 3. 2014. PMID: 24214317


  46. Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM. Profiling solute carrier transporters in the human blood-brain barrier. Volume 94 of Issue 6. 2013. PMID: 24013810


  47. Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. Volume 133 of Issue 2. 2013. PMID: 23992748


  48. Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M. International Transporter Consortium commentary on clinically important transporter polymorphisms. Volume 94 of Issue 1. 2013. PMID: 23778707


  49. Schlessinger A, Yee SW, Sali A, Giacomini KM. SLC classification: an update. Volume 94 of Issue 1. 2013. PMID: 23778706


  50. Giacomini KM, Huang SM. Transporters in drug development and clinical pharmacology. Volume 94 of Issue 1. 2013. PMID: 23778703


  51. Mushiroda T, Giacomini KM, Kubo M. Special Section on Pharmacogenomics: recent advances and future directions. Volume 58 of Issue 6. 2013. PMID: 23797326


  52. Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. Volume 58 of Issue 6. 2013. PMID: 23677058


  53. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). Volume 102 of Issue 9. 2013. PMID: 23649425


  54. Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L. Emerging transporters of clinical importance: an update from the International Transporter Consortium. Volume 94 of Issue 1. 2013. PMID: 23588305


  55. Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Volume 110 of Issue 14. Proceedings of the National Academy of Sciences of the United States of America 2013. PMID: 23509259


  56. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Volume 10 of Issue 2. 2013. PMID: 23268600


  57. Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Volume 56 of Issue 3. 2013. PMID: 23241029


  58. Schlessinger A, Khuri N, Giacomini KM, Sali A. Molecular modeling and ligand docking for solute carrier (SLC) transporters. Volume 13 of Issue 7. 2013. PMID: 23578028


  59. Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Renal transporters in drug development. Volume 53. 2012. PMID: 23140242


  60. Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM. Highlights from the International Transporter Consortium second workshop. Volume 92 of Issue 5. 2012. PMID: 23085880


  61. Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE. Metformin pathways: pharmacokinetics and pharmacodynamics. Volume 22 of Issue 11. 2012. PMID: 22722338


  62. Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM. The UCSF-FDA TransPortal: a public drug transporter database. Volume 92 of Issue 5. 2012. PMID: 23085876


  63. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Volume 93 of Issue 2. 2012. PMID: 23267855


  64. Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. Pharmacogenomics and patient care: one size does not fit all. Volume 4 of Issue 153. Science translational medicine 2012. PMID: 23019654


  65. Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Volume 2012. 2012. PMID: 23050139


  66. Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A. High selectivity of the ?-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. Volume 287 of Issue 45. The Journal of biological chemistry 2012. PMID: 22932902


  67. Smith DE, Rowland M, Giacomini KM, Amidon GL. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Volume 29 of Issue 9. 2012. PMID: 22814901


  68. Yee SW, Chen L, Giacomini KM. The role of ATM in response to metformin treatment and activation of AMPK. Volume 44 of Issue 4. 2012. PMID: 22456732


  69. Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Volume 13 of Issue 2. 2012. PMID: 22231567


  70. Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Volume 22 of Issue 1. 2011. PMID: 22147369


  71. Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Volume 18 of Issue 2. 2011. PMID: 22142827


  72. Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB. PharmGKB summary: methotrexate pathway. Volume 21 of Issue 10. 2011. PMID: 21317831


  73. Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Volume 90 of Issue 5. 2011. PMID: 21956618


  74. Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Volume 108 of Issue 38. Proceedings of the National Academy of Sciences of the United States of America 2011. PMID: 21885739


  76. Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters. Volume 41 of Issue 9. 2011. PMID: 21524191


  77. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Volume 17 of Issue 8. 2011. PMID: 21421857


  78. Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Volume 12 of Issue 3. 2011. PMID: 21383772


  79. Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. Functional characterization of liver enhancers that regulate drug-associated transporters. Volume 89 of Issue 4. 2011. PMID: 21368754


  81. Chen L, Xue L, Giacomini KM, Casida JE. GABAA receptor open-state conformation determines non-competitive antagonist binding. Volume 250 of Issue 3. 2010. PMID: 21111751


  82. Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM. Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Volume 28 of Issue 3. 2010. PMID: 21104302


  83. Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM. Consequences of POR mutations and polymorphisms. Volume 336 of Issue 1-2. 2010. PMID: 21070833


  84. Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL. Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. Volume 20 of Issue 11. 2010. PMID: 20940534


  85. Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM. Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Volume 20 of Issue 11. 2010. PMID: 20859243


  86. Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB. SLC19A1 pharmacogenomics summary. Volume 20 of Issue 11. 2010. PMID: 20811316


  87. Agrawal V, Choi JH, Giacomini KM, Miller WL. Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. Volume 20 of Issue 10. 2010. PMID: 20697309


  88. Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. Volume 299 of Issue 4. 2010. PMID: 20668102


  89. Chen L, Takizawa M, Chen E, Schlessinger A, Segenthelar J, Choi JH, Sali A, Kubo M, Nakamura S, Iwamoto Y, Iwasaki N, Giacomini KM. Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function. Volume 335 of Issue 1. 2010. PMID: 20639304


  90. More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM. Role of the copper transporter, CTR1, in platinum-induced ototoxicity. Volume 30 of Issue 28. 2010. PMID: 20631178


  91. Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu AG, Davis RL, Giacomini KM, Artursson P. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions. Volume 11 of Issue 6. 2010. PMID: 20567254


  92. More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Volume 9 of Issue 4. 2010. PMID: 20371711


  93. Yee SW, Chen L, Giacomini KM. Pharmacogenomics of membrane transporters: past, present and future. Volume 11 of Issue 4. 2010. PMID: 20350125


  94. Ianculescu AG, Friesema EC, Visser TJ, Giacomini KM, Scanlan TS. Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. Volume 6 of Issue 8. 2010. PMID: 20358049


  95. Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A. Comparison of human solute carriers. Volume 19 of Issue 3. 2010. PMID: 20052679


  96. . Membrane transporters in drug development. Volume 9 of Issue 3. 2010. PMID: 20190787


  97. Huang SM, Zhang L, Giacomini KM. The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA. Volume 87 of Issue 1. 2010. PMID: 20019700


  99. Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. Volume 27 of Issue 35. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009. PMID: 19901119


  100. Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. Volume 87 of Issue 1. 2009. PMID: 19890249


  101. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Volume 19 of Issue 10. 2009. PMID: 19745787


  102. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Volume 10 of Issue 10. 2009. PMID: 19842929


  103. Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A. A survey of integral alpha-helical membrane proteins. Volume 10 of Issue 4. 2009. PMID: 19760129


  104. Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. Volume 4 of Issue 9. PloS one 2009. PMID: 19742321


  105. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Volume 19 of Issue 7. 2009. PMID: 19483665


  106. McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. Volume 54 of Issue 1. 2009. PMID: 19528813


  107. Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Volume 9 of Issue 2. 2009. PMID: 19172157


  108. Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). Volume 329 of Issue 1. 2009. PMID: 19141711


  109. Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). Volume 328 of Issue 3. 2008. PMID: 19098160


  110. Ianculescu AG, Giacomini KM, Scanlan TS. Identification and characterization of 3-iodothyronamine intracellular transport. Volume 150 of Issue 4. 2008. PMID: 19074582


  111. Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM. Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. Volume 385 of Issue 3. 2008. PMID: 19061901


  112. Miller WL, Huang N, Agrawal V, Giacomini KM. Genetic variation in human P450 oxidoreductase. Volume 300 of Issue 1-2. 2008. PMID: 18930113


  113. Sorani MD, Manley GT, Giacomini KM. Genetic variation in human aquaporins and effects on phenotypes of water homeostasis. Volume 29 of Issue 9. 2008. PMID: 18470935


  114. Figg WD, Chau CH, Okita R, Preusch P, Tracy TS, McLeod H, Reed M, Pieper J, Knoell D, Miller K, Speedie M, Blouin R, Kroboth P, Koda-Kimble MA, Taylor P, Cohen J, Giacomini K. Pharm. D. pathways to biomedical research: the National Institutes of Health special conference on pharmacy research. Volume 28 of Issue 7. 2008. PMID: 18576897


  115. Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Volume 105 of Issue 26. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18579768


  116. Weiss ST, McLeod HL, Flockhart DA, Dolan ME, Benowitz NL, Johnson JA, Ratain MJ, Giacomini KM. Creating and evaluating genetic tests predictive of drug response. Volume 7 of Issue 7. 2008. PMID: 18587383


  117. Cropp CD, Yee SW, Giacomini KM. Genetic variation in drug transporters in ethnic populations. Volume 84 of Issue 3. 2008. PMID: 18528433


  118. Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT. Novel variants in human Aquaporin-4 reduce cellular water permeability. Volume 17 of Issue 15. 2008. PMID: 18511455


  120. Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. Volume 325 of Issue 3. 2008. PMID: 18364470


  121. Huang N, Agrawal V, Giacomini KM, Miller WL. Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations. Volume 105 of Issue 5. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18230729


  122. Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Volume 73 of Issue 4. 2008. PMID: 18216183


  123. Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Volume 6 of Issue 11. 2007. PMID: 17971785


  124. Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Volume 17 of Issue 9. 2007. PMID: 17700366


  125. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Volume 83 of Issue 2. 2007. PMID: 17609683


  126. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Volume 83 of Issue 3. 2007. PMID: 17609685


  127. Chen Y, Zhang S, Sorani M, Giacomini KM. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. Volume 322 of Issue 2. 2007. PMID: 17495125


  128. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. Volume 117 of Issue 5. The Journal of clinical investigation 2007. PMID: 17476361


  129. Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, Roden D, Krauss RM, Ratain M. Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing. Volume 8 of Issue 5. 2007. PMID: 17465717


  130. Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y. When good drugs go bad. Volume 446 of Issue 7139. 2007. PMID: 17460642


  131. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I. The pharmacogenetics research network: from SNP discovery to clinical drug response. Volume 81 of Issue 3. 2007. PMID: 17339863


  132. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST. Pharmacogenomics: challenges and opportunities. Volume 145 of Issue 10. Annals of internal medicine 2006. PMID: 17116919


  133. Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Chen Y, Komori T, Gray JW, Chen X, Lippard SJ, Giacomini KM. Organic cation transporters are determinants of oxaliplatin cytotoxicity. Volume 66 of Issue 17. Cancer research 2006. PMID: 16951202


  134. Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Volume 70 of Issue 5. 2006. PMID: 16931768


  135. Owen RP, Badagnani I, Giacomini KM. Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. Volume 281 of Issue 36. The Journal of biological chemistry 2006. PMID: 16840788


  136. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. Volume 318 of Issue 2. 2006. PMID: 16702441


  137. Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL. PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network. Volume 58 of Issue 1. 2006. PMID: 16507877


  138. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Volume 58 of Issue 1. 2006. PMID: 16507878


  139. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Volume 58 of Issue 1. 2006. PMID: 16507879


  140. Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. Volume 95 of Issue 1. 2006. PMID: 16307453


  141. Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM. Functional genomics of membrane transporters in human populations. Volume 16 of Issue 2. 2005. PMID: 16354753


  142. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Volume 290 of Issue 4. 2005. PMID: 16291576


  143. Owen RP, Lagpacan LL, Taylor TR, De La Cruz M, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. Volume 34 of Issue 1. 2005. PMID: 16214850


  144. Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Volume 15 of Issue 2. 2005. PMID: 15861032


  145. Ferrin TE, Huang CC, Greenblatt DM, Stryke D, Giacomini KM, Morris JH. Enhancing data sharing in collaborative research projects with DASH. 2005. PMID: 15759632


  146. Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Volume 5 of Issue 3. 2005. PMID: 15738947


  147. Urban TJ, Giacomini KM, Risch N. Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease. Volume 11 of Issue 1. Inflammatory bowel diseases 2005. PMID: 15674120


  148. Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1. Volume 56 of Issue 2. 2004. PMID: 15169925


  149. Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Volume 65 of Issue 3. 2004. PMID: 14978229


  150. Mangravite LM, Badagnani I, Giacomini KM. Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. Volume 479 of Issue 1-3. 2003. PMID: 14612157


  151. Leabman MK, Giacomini KM. Estimating the contribution of genes and environment to variation in renal drug clearance. Volume 13 of Issue 9. 2003. PMID: 12972957


  152. Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Volume 13 of Issue 8. 2003. PMID: 12893986


  153. Leabman MK, Huang CC, Stryke D, Johns SJ, Kawamoto M, Ferrin TE, DeYoung J, Taylor TR, De La Cruz M, Herskowitz I, Giacomini KM. PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2). Volume 55 of Issue 3. 2003. PMID: 12869664


  154. Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Volume 447 of Issue 5. 2003. PMID: 12856181


  155. Osato DH, Huang CC, Kawamoto M, Johns SJ, Stryke D, Wang J, Ferrin TE, Herskowitz I, Giacomini KM. Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. Volume 13 of Issue 5. 2003. PMID: 12724623


  156. Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Volume 100 of Issue 10. Proceedings of the National Academy of Sciences of the United States of America 2003. PMID: 12719534


  157. Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Volume 100 of Issue 10. Proceedings of the National Academy of Sciences of the United States of America 2003. PMID: 12719533


  158. Mangravite LM, Giacomini KM. Sorting of rat SPNT in renal epithelium is independent of N-glycosylation. Volume 20 of Issue 2. 2003. PMID: 12636174


  159. Mangravite LM, Xiao G, Giacomini KM. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Volume 284 of Issue 5. 2003. PMID: 12527552


  160. Stryke D, Huang CC, Kawamoto M, Johns SJ, Carlson EJ, Deyoung JA, Leabman MK, Herskowitz I, Giacomini KM, Ferrin TE. SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project. 2003. PMID: 12603056


  161. Gerstin KM, Dresser MJ, Giacomini KM. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. Volume 283 of Issue 2. 2002. PMID: 12110519


  162. Feng B, Shu Y, Giacomini KM. Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. Volume 41 of Issue 28. 2002. PMID: 12102636


  163. Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Volume 12 of Issue 5. 2002. PMID: 12142729


  164. Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM. Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. Volume 299 of Issue 1. 2001. PMID: 11561104


  165. Feng B, Dresser MJ, Shu Y, Johns SJ, Giacomini KM. Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3. Volume 40 of Issue 18. 2001. PMID: 11331016


  166. Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. Volume 280 of Issue 5. 2001. PMID: 11292631


  167. Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Volume 27 of Issue 4. 2001. PMID: 11279528


  168. Dresser MJ, Leabman MK, Giacomini KM. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. Volume 90 of Issue 4. 2001. PMID: 11170032


  169. Xiao G, Wang J, Tangen T, Giacomini KM. A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans. Volume 59 of Issue 2. 2001. PMID: 11160871


  170. Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM. Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes. Volume 28 of Issue 9. 2000. PMID: 10950861


  171. Gerstin KM, Dresser MJ, Wang J, Giacomini KM. Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine. Volume 17 of Issue 8. 2000. PMID: 11028933


  172. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Volume 28 of Issue 3. 2000. PMID: 10681378


  173. Dresser MJ, Gray AT, Giacomini KM. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). Volume 292 of Issue 3. 2000. PMID: 10688634


  174. Schaner ME, Wang J, Zhang L, Su SF, Gerstin KM, Giacomini KM. Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system. Volume 289 of Issue 3. 1999. PMID: 10336543


  175. Zhang L, Gorset W, Dresser MJ, Giacomini KM. The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. Volume 288 of Issue 3. 1999. PMID: 10027858


  176. Wang J, Giacomini KM. Characterization of a bioengineered chimeric Na+-nucleoside transporter. Volume 55 of Issue 2. 1999. PMID: 9927613


  177. Wang J, Giacomini KM. Serine 318 is essential for the pyrimidine selectivity of the N2 Na+-nucleoside transporter. Volume 274 of Issue 4. The Journal of biological chemistry 1999. PMID: 9890994


  178. Dresser MJ, Zhang L, Giacomini KM. Molecular and functional characteristics of cloned human organic cation transporters. Volume 12. 1999. PMID: 10742984


  180. Washington CB, Giacomini KM, Brett CM. Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Volume 15 of Issue 7. 1998. PMID: 9688074


  181. Zevin S, Schaner ME, Giacomini KM. Nicotine transport in a human choriocarcinoma cell line (JAR). Volume 87 of Issue 6. 1998. PMID: 9607946


  182. Terashita S, Dresser MJ, Zhang L, Gray AT, Yost SC, Giacomini KM. Molecular cloning and functional expression of a rabbit renal organic cation transporter. Volume 1369 of Issue 1. Biochimica et biophysica acta 1998. PMID: 9528667


  183. Zhang L, Brett CM, Giacomini KM. Role of organic cation transporters in drug absorption and elimination. Volume 38. 1998. PMID: 9597162


  184. Giacomini KM. Membrane transporters in drug disposition. Volume 25 of Issue 6. 1997. PMID: 9697080


  185. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM. Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. Volume 273 of Issue 6 Pt 2. 1997. PMID: 9435697


  186. Wang J, Giacomini KM. Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters. Volume 272 of Issue 46. The Journal of biological chemistry 1997. PMID: 9360950


  187. Ramanathan VK, Brett CM, Giacomini KM. Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Volume 1330 of Issue 1. Biochimica et biophysica acta 1997. PMID: 9375816


  188. Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM. Functional and molecular characteristics of Na(+)-dependent nucleoside transporters. Volume 14 of Issue 11. 1997. PMID: 9434270


  189. Schaner ME, Wang J, Zevin S, Gerstin KM, Giacomini KM. Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa). Volume 14 of Issue 10. 1997. PMID: 9358542


  190. Chun JK, Zhang L, Piquette-Miller M, Lau E, Tong LQ, Giacomini KM. Characterization of guanidine transport in human renal brush border membranes. Volume 14 of Issue 7. 1997. PMID: 9244153


  191. Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). Volume 272 of Issue 26. The Journal of biological chemistry 1997. PMID: 9195965


  192. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. Cloning and functional expression of a human liver organic cation transporter. Volume 51 of Issue 6. 1997. PMID: 9187257


  193. Chun JK, Piquette-Miller M, Zhang L, Giacomini KM. Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes. Volume 86 of Issue 6. 1997. PMID: 9188060


  194. Zevin S, Schaner ME, Illsley NP, Giacomini KM. Guanidine transport in a human choriocarcinoma cell line (JAR). Volume 14 of Issue 4. 1997. PMID: 9144721


  195. Ramanathan VK, Chung SJ, Giacomini KM, Brett CM. Taurine transport in cultured choroid plexus. Volume 14 of Issue 4. 1997. PMID: 9144722


  196. Washington CB, Giacomini KM. Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices. Volume 13 of Issue 8. 1996. PMID: 8865326


  197. Ramanathan VK, Hui AC, Brett CM, Giacomini KM. Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Volume 13 of Issue 6. 1996. PMID: 8792439


  198. Chung SJ, Ramanathan VK, Brett CM, Giacomini KM. Saturable disposition of taurine in the rat cerebrospinal fluid. Volume 276 of Issue 2. 1996. PMID: 8632336


  199. Gutierrez MM, Brett CM, Giacomini KM. Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Volume 8. 1996. PMID: 8791811


  200. Washington CB, Giacomini KM, Brett CM. Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Volume 8. 1996. PMID: 8791814


  201. Washington CB, Giacomini KM. Mechanisms of nucleobase transport in rabbit choroid plexus. Evidence for a Na(+)-dependent nucleobase transporter with broad substrate selectivity. Volume 270 of Issue 39. The Journal of biological chemistry 1995. PMID: 7559412


  202. Washington CB, Brett CM, Wu X, Giacomini KM. The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. Volume 274 of Issue 1. 1995. PMID: 7616386


  203. Lubic SP, Giacomini KM, Giacomini JC. The effects of modulation of calcium influx through the voltage-sensitive calcium channel on cardiomyocyte hypertrophy. Volume 27 of Issue 3. 1995. PMID: 7602609


  204. Lubic SP, Giacomini KM, Giacomini JC. Increased 1,4-dihydropyridine binding sites in serum-stimulated cardiomyocyte hypertrophy. Volume 270 of Issue 2. 1994. PMID: 8071861


  205. Wu X, Giacomini KM. Expression of the choroid plexus sodium-nucleoside cotransporter (N3) in Xenopus laevis oocytes. Volume 48 of Issue 2. 1994. PMID: 7519856


  206. Chung SJ, Ramanathan V, Giacomini KM, Brett CM. Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Volume 1193 of Issue 1. Biochimica et biophysica acta 1994. PMID: 8038178


  207. Giacomini KM, Markovich D, Werner A, Biber J, Wu X, Murer H. Expression of a renal Na(+)-nucleoside cotransport system (N2) in Xenopus laevis oocytes. Volume 427 of Issue 3-4. 1994. PMID: 7521031


  208. Wu X, Gutierrez MM, Giacomini KM. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Volume 1191 of Issue 1. Biochimica et biophysica acta 1994. PMID: 8155674


  209. Ott RJ, Chan JK, Ramanathan VK, Hui AC, Giacomini KM. Effect of phenylisothiocyanate on organic cation transport in opossum kidney cells. Volume 269 of Issue 1. 1994. PMID: 8169826


  210. Ott RJ, Giacomini KM. Stereoselective interactions of organic cations with the organic cation transporter in OK cells. Volume 10 of Issue 8. 1993. PMID: 8415403


  211. Gutierrez MM, Giacomini KM. Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney. Volume 1149 of Issue 2. Biochimica et biophysica acta 1993. PMID: 8323939


  212. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Volume 21 of Issue 4. 1993. PMID: 8104117


  213. Wu X, Hui AC, Giacomini KM. Formycin B elimination from the cerebrospinal fluid of the rat. Volume 10 of Issue 4. 1993. PMID: 8483848


  214. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Volume 10 of Issue 3. 1993. PMID: 8464817


  215. Hayes K, Morgan B, Giacomini K, Dockal S.. Caring for the community 1993. PMID:


  216. Frishman WH. Beta-adrenergic blockers as cardioprotective agents. Volume 70 of Issue 21. The American journal of cardiology 1992. PMID: 1361718


  217. Chang SW, Dutton D, Wang HL, He LS, Stearns R, Hui A, Giacomini KM, Ortiz de Montellano P, Voelkel NF. Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction. Volume 263 of Issue 4 Pt 1. 1992. PMID: 1415722


  218. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM. Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. Volume 267 of Issue 13. The Journal of biological chemistry 1992. PMID: 1315741


  219. Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. Nucleoside transport in brush border membrane vesicles from human kidney. Volume 1105 of Issue 1. Biochimica et biophysica acta 1992. PMID: 1567888


  220. Ott RJ, Hui AC, Giacomini KM. Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells. Volume 267 of Issue 1. The Journal of biological chemistry 1992. PMID: 1730580


  221. Ott RJ, Hui AC, Yuan G, Giacomini KM. Organic cation transport in human renal brush-border membrane vesicles. Volume 261 of Issue 3 Pt 2. 1991. PMID: 1832266


  222. Yuan G, Ott RJ, Salgado C, Giacomini KM. Transport of organic cations by a renal epithelial cell line (OK). Volume 266 of Issue 14. The Journal of biological chemistry 1991. PMID: 1827442


  223. Lam YW, Boyd RA, Chin SK, Chang D, Giacomini KM. Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide. Volume 31 of Issue 5. 1991. PMID: 2050827


  224. Whittico MT, Hui AC, Giacomini KM. Preparation of brush border membrane vesicles from bovine choroid plexus. Volume 25 of Issue 3. 1991. PMID: 1647471


  227. Koivukangas J, Louhisalmi Y. Computer-guided laser for neurosurgery. Volume 79 of Issue 4. 1990. PMID: 2102636


  228. Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini KM. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose. Volume 46 of Issue 4. 1989. PMID: 2791444


  230. Gisclon LG, Boyd RA, Williams RL, Giacomini KM. The effect of probenecid on the renal elimination of cimetidine. Volume 45 of Issue 4. 1989. PMID: 2702802


  231. Boyd RA, Chin SK, Don-Pedro O, Williams RL, Giacomini KM. The pharmacokinetics of the enantiomers of atenolol. Volume 45 of Issue 4. 1989. PMID: 2702798


  232. Boyd RA, Giacomini JC, Giacomini KM. Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium. Volume 12 of Issue 6. 1988. PMID: 2467082


  233. Whittico MT, Giacomini KM. Cimetidine elimination from the cerebrospinal fluid of the rat. Volume 5 of Issue 10. 1988. PMID: 3244614


  234. Giacomini KM, Hsyu PH, Gisclon LG. Renal transport of drugs: an overview of methodology with application to cimetidine. Volume 5 of Issue 8. 1988. PMID: 3072557


  235. Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF. Stereoselective binding of disopyramide to plasma proteins. Volume 5 of Issue 5. 1988. PMID: 3244643


  236. Hsyu PH, Wong FM, Giacomini KM. The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles. Volume 16 of Issue 3. 1988. PMID: 2900748


  238. Hsyu PH, Gisclon LG, Hui AC, Giacomini KM. Interactions of organic anions with the organic cation transporter in renal BBMV. Volume 254 of Issue 1 Pt 2. 1988. PMID: 2962517


  239. Boyd RA, Giacomini JC, Wong FM, Nelson WL, Giacomini KM. Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium. Volume 243 of Issue 1. 1987. PMID: 2822893


  240. Gisclon L, Wong FM, Giacomini KM. Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney. Volume 253 of Issue 1 Pt 2. 1987. PMID: 3605344


  241. Hsyu PH, Giacomini KM. Essential tyrosine residues in transport of organic cations in renal BBMV. Volume 252 of Issue 6 Pt 2. 1987. PMID: 2954470


  242. Hsyu PH, Giacomini KM. The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange. Volume 262 of Issue 9. The Journal of biological chemistry 1987. PMID: 2951380


  244. Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC. The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site. Volume 18 of Issue 9. 1986. PMID: 3783730


  245. Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF. In vivo interaction of the enantiomers of disopyramide in human subjects. Volume 14 of Issue 4. 1986. PMID: 3772736


  246. Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ. Posttraumatic complications and inflammatory mediators. Volume 121 of Issue 8. Archives of surgery (Chicago, Ill. : 1960) 1986. PMID: 3488050


  247. Giacomini JC, Nelson WL, Wong FM, Boyd R, Zobrist RH, Giacomini KM. Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel. Volume 35 of Issue 4. 1986. PMID: 2868731


  248. Hsyu PH, Giacomini KM. Stereoselective renal clearance of pindolol in humans. Volume 76 of Issue 5. The Journal of clinical investigation 1985. PMID: 4056049


  249. Giacomini JC, Nelson WL, Theodore L, Wong FM, Rood D, Giacomini KM. The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits. Volume 7 of Issue 3. 1985. PMID: 2410676


  250. Giacomini JC, Zobrist RH, Dave B, Giacomini KM. Verapamil interacts stereoselectively with the muscarinic receptor. Volume 2 of Issue 2. 1985. PMID: 24272619


  251. Giacomini KM, Massoud N, Wong FM, Giacomini JC. Decreased binding of verapamil to plasma proteins in patients with liver disease. Volume 6 of Issue 5. 1984. PMID: 6209501


  252. Giacomini KM, Wong FM, Tozer TN. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration. Volume 1 of Issue 4. 1984. PMID: 24277288


  253. Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF. High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma. Volume 307 of Issue 2. 1984. PMID: 6203924


  255. Schulz P, Turner-Tamiyasu K, Smith G, Giacomini KM, Blaschke TF. Amitriptyline disposition in young and elderly normal men. Volume 33 of Issue 3. 1983. PMID: 6825390


  256. Schulz P, Abang A, Giacomini JC, Blaschke TF, Giacomini KM. Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin. Volume 5 of Issue 4. 1983. PMID: 6659020


  257. Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF. Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man. Volume 25 of Issue 2. 1983. PMID: 6628503


  258. Giacomini KM, Abang A, Blaschke TF. Calculation of drug concentration in plasma after equilibrium dialysis. Volume 14 of Issue 5. 1982. PMID: 7138760


  259. Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Volume 66 of Issue 2. Circulation 1982. PMID: 7094252


  260. Smith GA, Schulz P, Giacomini KM, Blaschke TF. High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood. Volume 71 of Issue 5. 1982. PMID: 7097507


  261. Swezey SF, Giacomini KM, Abang A, Brass C, Stevens DA, Blaschke TF. Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography. Volume 227 of Issue 2. 1982. PMID: 6277970


  262. Giacomini KM, Swezey SE, Turner-Tamiyasu K, Blaschke TF. The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide. Volume 10 of Issue 1. 1982. PMID: 7069575


  263. Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. Volume 24 of Issue 5. 1981. PMID: 7241519


  264. Giacomini KM, Roberts SM, Levy G. Evaluation of methods for producing renal dysfunction in rats. Volume 70 of Issue 2. 1981. PMID: 7205211


  265. Giacomini KM, Giacomini JC, Blaschke TF. Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins. Volume 29 of Issue 24. 1980. PMID: 7213407


  266. Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF. The stereoselective disposition of disopyramide in the dog. Volume 2 of Issue 6. 1980. PMID: 6160331


  267. Giacomini KM, Cox BM, Blaschke TF. Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum. Volume 27 of Issue 13. 1980. PMID: 7421405


  268. Giacomini KM, Swezey SE, Giacomini JC, Blaschke TF. Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma. Volume 27 of Issue 9. 1980. PMID: 7412503


  270. Giacomini KM, Nakeeb SM, Levy G. Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs. Volume 69 of Issue 7. 1980. PMID: 7391940


  271. Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Volume 27 of Issue 5. 1980. PMID: 7371364


  272. Giacomini KM, Gibson TP, Levy G. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Volume 27 of Issue 4. 1980. PMID: 7357810


  273. Jones MR, Kopple JD, Swendseid ME. Phenylalanine metabolism in uremic and normal man. Volume 14 of Issue 2. Kidney international 1978. PMID: 357810


  274. Levy G, Giacomini KM. Rational aspirin dosage regimens. Volume 23 of Issue 3. 1978. PMID: 627128


  275. Giacomini KM, Gibson TP, Levy G. Plasma protein binding of d-propoxyphene in normal subjects and anephric patients. Volume 18 of Issue 2-3. 1978. PMID: 624774


  276. Soles C, Giacomini KM, Roberts SM, Giacomini JC. Soles C, Giacomini KM, Roberts SM, Giacomini JC.. A Convenient Method for Repetitive Blood Sampling in the Dog 1978. PMID: