Recently Awarded Grants in the Division of General Internal Medicine
Title: Working to reduce smoking among young Americans
Principal Investigator: Steven Schroeder, MD
Period: 07/01/2015 – 06/30/2016
Agency: American Legacy Foundation
This request is intended to build on work done under Legacy grants between 2006 and 2015 that involved mobilizing governmental organizations (federal, state, and local) plus private groups (e.g., professional societies and advocacy groups) to stimulate smoking cessation among persons with behavioral health issues. This new proposal would focus on young smokers in vulnerable categories, specifically targeting smokers in the criminal justice system, the military, community colleges, the LGBT population, and persons with behavioral health problems.
Title: Mediators of Atherosclerosis in South Asians Living in America
Principal Investigator: Alka Kanaya, MD
Period: 04/01/2015 – 28/28/2019
Agency: National Heart, Lung, and Blood Institute (NHLBI)
Type: R01 (Renewal)
South Asians have high rates of heart disease that cannot be explained by traditional cardiovascular risk factors. Coronary artery calcium (CAC) and plaque measured from CT scans can predict heart disease events and provides more information than traditional risk factors. We have established a unique South Asian cohort which has a high burden of CAC and other cardiovascular risk factors. Studying the impact of CAC and other plaque characteristics in this high risk ethnic cohort could provide novel insights into the origins of cardiovascular disease in general.
Our aims are to:
- Investigate the rate of CAC progression among South Asians after 4 years of follow-up, and compare annualized progression rates to the MESA race/ethnic groups;
- Determine the prevalence and correlates of advanced coronary plaque characteristics among South Asians and compare the prevalence and correlates with the four MESA race/ethnic groups; and
- Determine whether CAC and coronary plaque characteristics are associated with incident myocardial infarction and ASCVD events among South Asians