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Faculty Profiles

Mary Whooley, MD
M_MED-DGIM-VAMC
Professor

VAMC 18
San Francisco, CA 94121
415-750-2093
mary.whooley@va.gov

Mary Whooley, MD, FACP, FAHA, FAHA is a primary care physician, health services researcher, Professor of Medicine, Epidemiology & Biostatistics at the University of California, San Francisco (UCSF), and Director of Cardiac Rehabilitation at the San Francisco VA (SFVA) Health Care System. Dr. Whooley currently serves as Principal Investigator (PI) of the VA Measurement Science Quality Enhancement Research Initiative (QUERI), SFVA site-PI for the UCSF Fellowship in Clinical Informatics, and SFVA site-PI for the Million Veteran Program. She also serves as PI of a PCORI-funded study, entitled "Improving Delivery of Patient-Centered Cardiac Rehabilitation" and UCSF site PI for the Patient-Centered Scalable National Network for Effectiveness Research (pSCANNER) project, one of 13 PCORI-funded Clinical Data Research Networks.


Dr. Whooley's prior work was focused on understanding the links between mental and physical health in patients with cardiovascular disease. She validated a simple, two-question screening instrument for depression that is now referred to as The Whooley Questions and used world-wide (JGIM, 1997). She then served as PI of the Heart and Soul Study, a still ongoing, 20-year prospective cohort study of >1000 patients with coronary heart disease. The Heart and Soul Study demonstrated that (a) depression is more strongly associated with health-related quality of life than objective measures of cardiac disease severity (JAMA, 2003) and (b) the adverse cardiovascular outcomes associated with depression are largely explained by poor health behaviors, especially physical inactivity (JAMA, 2008). Dr. Whooley has mentored numerous junior investigators and coauthored more than 200 publications.

Education and Training

Location Degree or Training Specialty Date
American Board of Preventive Medicine Subspecialty Certification Clinical Informatics 2016
University of California, San Francisco Training Certificate Implementation Science 2013
University of California, San Francisco Postdoctoral Fellowship Health Services Research 1998
University of California, San Francisco Chief Residency Internal Medicine 1996
University of California, San Francisco Internship and Residency Internal Medicine 1995
Boston University School of Medicine Doctor of Medicine Medicine 1991
Yale University Bachelor of Arts Psychology 1987

Interests

Big Data, Cardiac Rehabilitation, Cardiovascular Outcomes Research, Clinical Informatics, Depression Screening

Awards and Honors
2015   Stephen B. Hulley Award for Excellence in Teaching, UCSF Clinical and Translational Sciences Institute, 2015
2014   Elected to Membership, Association of American Physicians (AAP), 2014
2011   Elected to Fellowship, American College of Cardiology (ACC), 2011
2011   Elected to Membership, American Society for Clinical Investigation (ASCI), 2011
2009   Outstanding Mentor of the Year, SF Bay Area Clinical Research Symposium, 2009
2009   Elected to Fellowship, American Heart Association (AHA), 2009
2006   Resident Research Mentorship Award, UCSF Department of Medicine, 2006
2006   Herbert Weiner Early Career Award, American Psychosomatic Society, 2006
2004   Advanced Career Development Award, VA Health Services Research & Development, 2004
2002   Hellman Award for Early Career Faculty, University of California, San Francisco, 2002
2001   Beeson Faculty Scholars Award, American Federation for Aging Research, 2001
2001   Physician Faculty Scholars Award, Robert Wood Johnson Foundation, 2001
1998   Career Development Award, VA Health Services Research & Development, 1998
1997   Young Investigator Award, American Society Bone & Mineral Research, 1997
1993   Keith Johnson Award, UCSF Department of Medicine, 1993
1992   Krevans Award for Clinical Excellence, UCSF Department of Medicine, 1992
1991   Elected to Membership, Alpha Omega Alpha Honor Society, 1991

Related Web Sites

Recent Articles (238)

Park M, Maristany D, Huang D, Shlipak MG, Whooley M. Associations of TNFR1 with kidney function outcomes by age, gender, and baseline kidney function status: Data from the Heart and Soul Study. Data Brief. 2017 Oct; 14:366-370.

Park LG, Collins EG, Shim JK, Whooley MA. Comparing Mobile Health Strategies to Improve Medication Adherence for Veterans With Coronary Heart Disease (Mobile4Meds): Protocol for a Mixed-Methods Study. JMIR Res Protoc. 2017 Jul 18; 6(7):e134.

Simoneau G, Levis B, Cuijpers P, Ioannidis JPA, Patten SB, Shrier I, Bombardier CH, de Lima Osório F, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Wittkampf KA, Yeung AS, Thombs BD, Benedetti A. A comparison of bivariate, multivariate random-effects, and Poisson correlated gamma-frailty models to meta-analyze individual patient data of ordinal scale diagnostic tests. Biom J. 2017 Jul 10.

Bachmann JM, Shah AS, Duncan MS, Greevy RA, Graves AJ, Ni S, Ooi HH, Wang TJ, Thomas RJ, Whooley MA, Freiberg MS. Cardiac rehabilitation and readmissions after heart transplantation. J Heart Lung Transplant. 2017 May 23.

Park M, Maristany D, Huang D, Shlipak MG, Whooley M. Associations of tumor necrosis factor alpha receptor type 1 with kidney function decline, cardiovascular events, and mortality risk in persons with coronary artery disease: Data from the Heart and Soul Study. Atherosclerosis. 2017 Aug; 263:68-73.

Levis B, Benedetti A, Levis AW, Ioannidis JPA, Shrier I, Cuijpers P, Gilbody S, Kloda LA, McMillan D, Patten SB, Steele RJ, Ziegelstein RC, Bombardier CH, de Lima Osório F, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Loureiro SR, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Williams LS, Wittkampf KA, Yeung AS, Thombs BD. Selective Cutoff Reporting in Studies of Diagnostic Test Accuracy: A Comparison of Conventional and Individual-Patient-Data Meta-Analyses of the Patient Health Questionnaire-9 Depression Screening Tool. Am J Epidemiol. 2017 May 15; 185(10):954-964.

Mishra RK, Judson G, Christenson RH, DeFilippi C, Wu AHB, Whooley MA. The Association of Five-Year Changes in the Levels of N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP) with Subsequent Heart Failure and Death in Patients with Stable Coronary Artery Disease: The Heart and Soul Study. Cardiology. 2017; 137(4):201-206.

Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, Burmeister M, Cohen-Woods S, Etain B, Fisher HL, Goldman N, Guillaume S, Horwood J, Juhasz G, Lester KJ, Mandelli L, Middeldorp CM, Olié E, Villafuerte S, Air TM, Araya R, Bowes L, Burns R, Byrne EM, Coffey C, Coventry WL, Gawronski KA, Glei D, Hatzimanolis A, Hottenga JJ, Jaussent I, Jawahar C, Jennen-Steinmetz C, Kramer JR, Lajnef M, Little K, Zu Schwabedissen HM, Nauck M, Nederhof E, Petschner P, Peyrot WJ, Schwahn C, Sinnamon G, Stacey D, Tian Y, Toben C, Van der Auwera S, Wainwright N, Wang JC, Willemsen G, Anderson IM, Arolt V, Åslund C, Bagdy G, Baune BT, Bellivier F, Boomsma DI, Courtet P, Dannlowski U, de Geus EJ, Deakin JF, Easteal S, Eley T, Fergusson DM, Goate AM, Gonda X, Grabe HJ, Holzman C, Johnson EO, Kennedy M, Laucht M, Martin NG, Munafò MR, Nilsson KW, Oldehinkel AJ, Olsson CA, Ormel J, Otte C, Patton GC, Penninx BW, Ritchie K, Sarchiapone M, Scheid JM, Serretti A, Smit JH, Stefanis NC, Surtees PG, Völzke H, Weinstein M, Whooley M, Nurnberger JI, Breslau N, Bierut LJ. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry. 2017 Apr 04.

Smolderen KG, Buchanan DM, Gosch K, Whooley M, Chan PS, Vaccarino V, Parashar S, Shah AJ, Ho PM, Spertus JA. Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction: Insights From the TRIUMPH Registry (Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status). Circulation. 2017 May 02; 135(18):1681-1689.

Park LG, Schopfer DW, Zhang N, Shen H, Whooley MA. Participation in Cardiac Rehabilitation Among Patients With Heart Failure. J Card Fail. 2017 May; 23(5):427-431.

Goglin SE, Farzaneh-Far R, Epel ES, Lin J, Blackburn EH, Whooley MA. Correction: Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. PLoS One. 2016; 11(12):e0168868.

Towfighi A, Ovbiagele B, El Husseini N, Hackett ML, Jorge RE, Kissela BM, Mitchell PH, Skolarus LE, Whooley MA, Williams LS. Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2017 Feb; 48(2):e30-e43.

Schopfer DW, Takemoto S, Allsup K, Helfrich CD, Ho PM, Forman DE, Whooley MA. Notice of Retraction and Replacement. Schopfer DW, et al. Cardiac Rehabilitation Use Among Veterans With Ischemic Heart Disease. JAMA Intern Med. 2014;174(10):1687-1689. JAMA Intern Med. 2016 11 01; 176(11):1726-1727.

Goglin SE, Farzaneh-Far R, Epel ES, Lin J, Blackburn EH, Whooley MA. Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. PLoS One. 2016; 11(10):e0160748.

Wang EY, Dixson J, Schiller NB, Whooley MA. Causes and Predictors of Death in Patients With Coronary Heart Disease (from the Heart and Soul Study). Am J Cardiol. 2017 Jan 01; 119(1):27-34.

Schopfer DW, Regan M, Heidenreich PA, Whooley MA. Depressive Symptoms, Cardiac Disease Severity, and Functional Status in Patients With Coronary Artery Disease (from the Heart and Soul Study). Am J Cardiol. 2016 Nov 01; 118(9):1287-1292.

Sin NL, Kumar AD, Gehi AK, Whooley MA. Direction of Association Between Depressive Symptoms and Lifestyle Behaviors in Patients with Coronary Heart Disease: the Heart and Soul Study. Ann Behav Med. 2016 Aug; 50(4):523-32.

Forman DE, Fix GM, McDannold S, McIntosh N, Schopfer DW, Whooley MA, Charns MP. Decisive Bearing of Organizational Dynamics on the Application and Success of Hospital-Based Cardiac Rehabilitation. Mayo Clin Proc. 2016 Jul; 91(7):975-7.

Schopfer DW, Priano S, Allsup K, Helfrich CD, Ho PM, Rumsfeld JS, Forman DE, Whooley MA. Factors Associated With Utilization of Cardiac Rehabilitation Among Patients With Ischemic Heart Disease in the Veterans Health Administration: A QUALITATIVE STUDY. J Cardiopulm Rehabil Prev. 2016 May-Jun; 36(3):167-73.

Whooley MA. Screening for Depression--A Tale of Two Questions. JAMA Intern Med. 2016 Apr; 176(4):436-8.

Grenon SM, Owens CD, Alley H, Perez S, Whooley MA, Neylan TC, Aschbacher K, Gasper WJ, Hilton JF, Cohen BE. Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans. J Am Heart Assoc. 2016 Mar 23; 5(3):e003010.

Park LG, Beatty A, Stafford Z, Whooley MA. Mobile Phone Interventions for the Secondary Prevention of Cardiovascular Disease. Prog Cardiovasc Dis. 2016 May-Jun; 58(6):639-50.

Yoon J, Fonarow GC, Groeneveld PW, Teerlink JR, Whooley MA, Sahay A, Heidenreich PA. Patient and Facility Variation in Costs of VA Heart Failure Patients. JACC Heart Fail. 2016 Jul; 4(7):551-558.

Sin NL, Moskowitz JT, Whooley MA. Positive Affect and Health Behaviors Across 5 Years in Patients With Coronary Heart Disease: The Heart and Soul Study. Psychosom Med. 2015 Nov-Dec; 77(9):1058-66.

Park M, Kulkarni A, Beatty A, Ganz P, Regan M, Vittinghoff E, Whooley M. Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study. Atherosclerosis. 2015 Dec; 243(2):546-52.

Doll JA, Hellkamp A, Ho PM, Kontos MC, Whooley MA, Peterson ED, Wang TY. Participation in Cardiac Rehabilitation Programs Among Older Patients After Acute Myocardial Infarction. JAMA Intern Med. 2015 Oct; 175(10):1700-2.

Olson KA, Beatty AL, Heidecker B, Regan MC, Brody EN, Foreman T, Kato S, Mehler RE, Singer BS, Hveem K, Dalen H, Sterling DG, Lawn RM, Schiller NB, Williams SA, Whooley MA, Ganz P. Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts. Eur Heart J. 2015 Dec 21; 36(48):3426-34.

Cohen B, Whooley M, Neylan T. Effects of posttraumatic stress disorder on cardiovascular health: Findings from the Mind Your Heart Study. Psychoneuroendocrinology. 2015 Nov; 61:7.

Doll JA, Hellkamp A, Thomas L, Ho PM, Kontos MC, Whooley MA, Boyden TF, Peterson ED, Wang TY. Effectiveness of cardiac rehabilitation among older patients after acute myocardial infarction. Am Heart J. 2015 Nov; 170(5):855-64.

Beatty AL, Ku IA, Bibbins-Domingo K, Christenson RH, DeFilippi CR, Ganz P, Ix JH, Lloyd-Jones D, Omland T, Sabatine MS, Schiller NB, Shlipak MG, Skali H, Takeuchi M, Vittinghoff E, Whooley MA. Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study. J Am Heart Assoc. 2015 Jul 06; 4(7).

Mishra RK, Tietjens J, Regan M, Whooley MA, Schiller NB. The Prognostic Utility of Echo-Estimated Left Ventricular End-Diastolic Pressure-Volume Relationship in Stable Coronary Artery Disease: The Heart and Soul Study. Echocardiography. 2015 Nov; 32(11):1639-46.

Saha SA, Beatty AL, Mishra RK, Whooley MA, Schiller NB. Usefulness of an Echocardiographic Composite Cardiac Calcium Score to Predict Death in Patients With Stable Coronary Artery Disease (from the Heart and Soul Study). Am J Cardiol. 2015 Jul 01; 116(1):50-8.

Sin NL, Yaffe K, Whooley MA. Depressive symptoms, cardiovascular disease severity, and functional status in older adults with coronary heart disease: the heart and soul study. J Am Geriatr Soc. 2015 Jan; 63(1):8-15.

Wingenfeld K, Whooley MA, Neylan TC, Otte C, Cohen BE. Effect of current and lifetime posttraumatic stress disorder on 24-h urinary catecholamines and cortisol: results from the Mind Your Heart Study. Psychoneuroendocrinology. 2015 Feb; 52:83-91.

Park M, Vittinghoff E, Shlipak MG, Mishra R, Whooley M, Bansal N. Associations of N-terminal pro-B-type natriuretic peptide with kidney function decline in persons without clinical heart failure in the Heart and Soul Study. Am Heart J. 2014 Dec; 168(6):931-9.e2.

Schopfer DW, Takemoto S, Allsup K, Helfrich CD, Ho PM, Forman DE, Whooley MA. Cardiac rehabilitation use among veterans with ischemic heart disease. JAMA Intern Med. 2014 Oct; 174(10):1687-9.

Kreibig SD, Whooley MA, Gross JJ. Social integration and mortality in patients with coronary heart disease: findings from the Heart and Soul Study. Psychosom Med. 2014 Oct; 76(8):659-68.

Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH, Mukamal KJ. The authors reply. Am J Epidemiol. 2014 Oct 01; 180(7):758.

Jarvie JL, Whooley MA, Regan MC, Sin NL, Cohen BE. Effect of physical activity level on biomarkers of inflammation and insulin resistance over 5 years in outpatients with coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2014 Oct 15; 114(8):1192-7.

Mishra RK, Beatty AL, Jaganath R, Regan M, Wu AH, Whooley MA. B-type natriuretic peptides for the prediction of cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study. J Am Heart Assoc. 2014 Jul 22; 3(4).

Beatty AL, Spertus JA, Whooley MA. Frequency of angina pectoris and secondary events in patients with stable coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2014 Oct 01; 114(7):997-1002.

Park LG, Howie-Esquivel J, Whooley MA, Dracup K. Psychosocial factors and medication adherence among patients with coronary heart disease: A text messaging intervention. Eur J Cardiovasc Nurs. 2015 Jun; 14(3):264-73.

Wong JM, Sin NL, Whooley MA. A comparison of cook-medley hostility subscales and mortality in patients with coronary heart disease: data from the heart and soul study. Psychosom Med. 2014 May; 76(4):311-7.

Beatty AL, Li S, Thomas L, Amsterdam EA, Alexander KP, Whooley MA. Trends in referral to cardiac rehabilitation after myocardial infarction: data from the National Cardiovascular Data Registry 2007 to 2012. J Am Coll Cardiol. 2014 Jun 17; 63(23):2582-3.

Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH, Mukamal KJ. Welles et al. respond to "Low vitamin D and cardiovascular disease". Am J Epidemiol. 2014 Jun 01; 179(11):1291-2.

Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH, Mukamal KJ. Vitamin D deficiency and cardiovascular events in patients with coronary heart disease: data from the Heart and Soul Study. Am J Epidemiol. 2014 Jun 01; 179(11):1279-87.

Zimmermann-Viehoff F, Kuehl LK, Danker-Hopfe H, Whooley MA, Otte C. Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study. Psychol Med. 2014 Oct; 44(14):2975-84.

Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. J Vasc Surg. 2014 Aug; 60(2):396-403.

Wong JM, Welles CC, Azarbal F, Whooley MA, Schiller NB, Turakhia MP. Relation of left atrial dysfunction to ischemic stroke in patients with coronary heart disease (from the heart and soul study). Am J Cardiol. 2014 May 15; 113(10):1679-84.

Colangelo LA, He K, Whooley MA, Daviglus ML, Morris S, Liu K. Selenium exposure and depressive symptoms: the Coronary Artery Risk Development in Young Adults Trace Element Study. Neurotoxicology. 2014 Mar; 41:167-74.

Agarwal I, Ide N, Ix JH, Kestenbaum B, Lanske B, Schiller NB, Whooley MA, Mukamal KJ. Fibroblast growth factor-23 and cardiac structure and function. J Am Heart Assoc. 2014 Feb 13; 3(1):e000584.

Azarbal F, Welles CC, Wong JM, Whooley MA, Schiller NB, Turakhia MP. Association of CHADS2, CHA2DS2-VASc, and R2CHADS2 scores with left atrial dysfunction in patients with coronary heart disease (from the Heart and Soul study). Am J Cardiol. 2014 Apr 01; 113(7):1166-72.

Smolderen KG, Whooley MA. Psychological distress and medication adherence: creating order out of chaos? Circ Cardiovasc Qual Outcomes. 2013 Nov; 6(6):615-6.

Beatty AL, Fukuoka Y, Whooley MA. Using mobile technology for cardiac rehabilitation: a review and framework for development and evaluation. J Am Heart Assoc. 2013 Nov 01; 2(6):e000568.

Park M, Vittinghoff E, Ganz P, Peralta CA, Whooley M, Shlipak MG. Role of soluble endothelial cell-selective adhesion molecule biomarker in albuminuria and kidney function changes in patients with coronary artery disease: the Heart and Soul Study. Arterioscler Thromb Vasc Biol. 2014 Jan; 34(1):231-6.

Hendrickson CM, Neylan TC, Na B, Regan M, Zhang Q, Cohen BE. Lifetime trauma exposure and prospective cardiovascular events and all-cause mortality: findings from the Heart and Soul Study. Psychosom Med. 2013 Nov-Dec; 75(9):849-55.

Schopfer DW, Ku IA, Regan M, Whooley MA. Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study). Am Heart J. 2014 Feb; 167(2):186-192.e1.

Wong JM, Na B, Regan MC, Whooley MA. Hostility, health behaviors, and risk of recurrent events in patients with stable coronary heart disease: findings from the Heart and Soul Study. J Am Heart Assoc. 2013 Sep 30; 2(5):e000052.

Dinenberg RE, McCaslin SE, Bates MN, Cohen BE. Social support may protect against development of posttraumatic stress disorder: findings from the Heart and Soul Study. Am J Health Promot. 2014 May-Jun; 28(5):294-7.

Waldrop AE, Cohen BE. Trauma exposure predicts alcohol, nicotine, and drug problems beyond the contribution of PTSD and depression in patients with cardiovascular disease: data from the Heart and Soul Study. Am J Addict. 2014 Jan-Feb; 23(1):53-61.

Grenon SM, Vittinghoff E, Owens CD, Conte MS, Whooley M, Cohen BE. Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: insights from the Heart and Soul Study. Vasc Med. 2013 Aug; 18(4):176-84.

Hoen PW, Denollet J, de Jonge P, Whooley MA. Positive affect and survival in patients with stable coronary heart disease: findings from the Heart and Soul Study. J Clin Psychiatry. 2013 Jul; 74(7):716-22.

Prather AA, Epel ES, Cohen BE, Neylan TC, Whooley MA. Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the Heart and Soul Study. J Psychiatr Res. 2013 Sep; 47(9):1228-35.

Puterman E, Epel ES, Lin J, Blackburn EH, Gross JJ, Whooley MA, Cohen BE. Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study. Brain Behav Immun. 2013 Oct; 33:65-73.

Beatty AL, Ku IA, Christenson RH, DeFilippi CR, Schiller NB, Whooley MA. High-sensitivity cardiac troponin T levels and secondary events in outpatients with coronary heart disease from the Heart and Soul Study. JAMA Intern Med. 2013 May 13; 173(9):763-9.

Elderon L, Whooley MA. Depression and cardiovascular disease. Prog Cardiovasc Dis. 2013 May-Jun; 55(6):511-23.

Palomino HL, Rifkin DE, Anderson C, Criqui MH, Whooley MA, Ix JH. 24-hour urine phosphorus excretion and mortality and cardiovascular events. Clin J Am Soc Nephrol. 2013 Jul; 8(7):1202-10.

Dominguez JR, Shlipak MG, Whooley MA, Ix JH. Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes. J Am Soc Nephrol. 2013 Mar; 24(4):647-54.

Singh KJ, Cohen BE, Na B, Regan M, Schiller NB, Whooley MA. Alcohol consumption and 5-year change in left atrial volume among patients with coronary heart disease: results from the Heart and Soul study. J Card Fail. 2013 Mar; 19(3):183-9.

Beatty AL, Schiller NB, Whooley MA. Moderate exercise for improvement in 6-minute walk test performance in stable coronary heart disease--reply. JAMA Intern Med. 2013 Jan 28; 173(2):169.

Whooley MA, Wong JM. Depression and cardiovascular disorders. Annu Rev Clin Psychol. 2013; 9:327-54.

Bansal N, Whooley MA, Regan M, McCulloch CE, Ix JH, Epel E, Blackburn E, Lin J, Hsu CY. Association between kidney function and telomere length: the heart and soul study. Am J Nephrol. 2012; 36(5):405-11.

Welles CC, Schafer AL, Vittinghoff E, Shlipak MG, Whooley MA, Ix JH. Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study). Am J Cardiol. 2012 Dec 15; 110(12):1729-34.

Grenon SM, Hiramoto J, Smolderen KG, Vittinghoff E, Whooley MA, Cohen BE. Association between depression and peripheral artery disease: insights from the heart and soul study. J Am Heart Assoc. 2012 Aug; 1(4):e002667.

Duivis HE, Kupper N, Penninx BW, Na B, de Jonge P, Whooley MA. Depressive symptoms and white blood cell count in coronary heart disease patients: prospective findings from the Heart and Soul Study. Psychoneuroendocrinology. 2013 Apr; 38(4):479-87.

Beatty AL, Schiller NB, Whooley MA. Six-minute walk test as a prognostic tool in stable coronary heart disease: data from the heart and soul study. Arch Intern Med. 2012 Jul 23; 172(14):1096-102.

Razykov I, Ziegelstein RC, Whooley MA, Thombs BD. The PHQ-9 versus the PHQ-8--is item 9 useful for assessing suicide risk in coronary artery disease patients? Data from the Heart and Soul Study. J Psychosom Res. 2012 Sep; 73(3):163-8.

Schopfer DW, Whooley MA, Stamos TD. Hospital compliance with performance measures and 30-day outcomes in patients with heart failure. Am Heart J. 2012 Jul; 164(1):80-6.

Bansal N, Hsu CY, Whooley M, Berg AH, Ix JH. Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study. Am J Nephrol. 2012; 35(6):483-90.

Whooley MA. Diagnosis and treatment of depression in adults with comorbid medical conditions: a 52-year-old man with depression. JAMA. 2012 May 02; 307(17):1848-57.

Otte C, Zhao S, Whooley MA. Statin use and risk of depression in patients with coronary heart disease: longitudinal data from the Heart and Soul Study. J Clin Psychiatry. 2012 May; 73(5):610-5.

O'Donovan A, Neylan TC, Metzler T, Cohen BE. Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study. Brain Behav Immun. 2012 May; 26(4):642-9.

Welles CC, Ku IA, Kwan DM, Whooley MA, Schiller NB, Turakhia MP. Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol. 2012 Feb 14; 59(7):673-80.

Dubin R, Li Y, Ix JH, Shlipak MG, Whooley M, Peralta CA. Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study. Am Heart J. 2012 Feb; 163(2):274-9.

Holtz JE, Upadhyaya DS, Cohen BE, Na B, Schiller NB, Whooley MA. Mitral annular calcium, inducible myocardial ischemia, and cardiovascular events in outpatients with coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2012 Apr 15; 109(8):1092-6.

Beatty AL, Zhang MH, Ku IA, Na B, Schiller NB, Whooley MA. Adiponectin is associated with increased mortality and heart failure in patients with stable ischemic heart disease: data from the Heart and Soul Study. Atherosclerosis. 2012 Feb; 220(2):587-92.

Krauss J, Farzaneh-Far R, Puterman E, Na B, Lin J, Epel E, Blackburn E, Whooley MA. Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study. PLoS One. 2011; 6(11):e26983.

Zen AL, Whooley MA, Zhao S, Cohen BE. Post-traumatic stress disorder is associated with poor health behaviors: findings from the heart and soul study. Health Psychol. 2012 Mar; 31(2):194-201.

Whooley MA, Wong J. Hostility and cardiovascular disease. J Am Coll Cardiol. 2011 Sep 13; 58(12):1229-30.

Elderon L, Smolderen KG, Na B, Whooley MA. Accuracy and prognostic value of American Heart Association: recommended depression screening in patients with coronary heart disease: data from the Heart and Soul Study. Circ Cardiovasc Qual Outcomes. 2011 Sep; 4(5):533-40.

Ix JH, Chonchol M, Laughlin GA, Shlipak MG, Whooley MA. Relation of sex and estrogen therapy to serum fibroblast growth factor 23, serum phosphorus, and urine phosphorus: the Heart and Soul Study. Am J Kidney Dis. 2011 Nov; 58(5):737-45.

Welles CC, Whooley MA, Na B, Ganz P, Schiller NB, Turakhia MP. The CHADS2 score predicts ischemic stroke in the absence of atrial fibrillation among subjects with coronary heart disease: data from the Heart and Soul Study. Am Heart J. 2011 Sep; 162(3):555-61.

Mishra RK, Devereux RB, Cohen BE, Whooley MA, Schiller NB. Prediction of heart failure and adverse cardiovascular events in outpatients with coronary artery disease using mitral E/A ratio in conjunction with e-wave deceleration time: the heart and soul study. J Am Soc Echocardiogr. 2011 Oct; 24(10):1134-40.

Duivis HE, de Jonge P, Penninx BW, Na BY, Cohen BE, Whooley MA. Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. Am J Psychiatry. 2011 Sep; 168(9):913-20.

Crisel RK, Farzaneh-Far R, Na B, Whooley MA. First-degree atrioventricular block is associated with heart failure and death in persons with stable coronary artery disease: data from the Heart and Soul Study. Eur Heart J. 2011 Aug; 32(15):1875-80.

Hoen PW, de Jonge P, Na BY, Farzaneh-Far R, Epel E, Lin J, Blackburn E, Whooley MA. Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study. Psychosom Med. 2011 Sep; 73(7):541-7.

Bansal N, Hsu CY, Zhao S, Whooley MA, Ix JH. Relation of body mass index to urinary creatinine excretion rate in patients with coronary heart disease. Am J Cardiol. 2011 Jul 15; 108(2):179-84.

Moyers B, Farzaneh-Far R, Harris WS, Garg S, Na B, Whooley MA. Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the heart and soul study). Am J Cardiol. 2011 Apr 15; 107(8):1149-54.

Berger J, Ren X, Na B, Whooley MA, Schiller NB. Relation of concentric remodeling to adverse outcomes in patients with stable coronary artery disease (from the Heart and Soul Study). Am J Cardiol. 2011 Jun 01; 107(11):1579-84.

Ristow B, Na B, Ali S, Whooley MA, Schiller NB. Left ventricular outflow tract and pulmonary artery stroke distances independently predict heart failure hospitalization and mortality: the Heart and Soul Study. J Am Soc Echocardiogr. 2011 May; 24(5):565-72.

Shlipak MG, Weekley CC, Li Y, Hansson LO, Larsson A, Whooley M. Comparison of cardiovascular prognosis by 3 serum cystatin C methods in the Heart and Soul Study. Clin Chem. 2011 May; 57(5):737-45.

Shlipak MG, Li Y, Fox C, Coresh J, Grunfeld C, Whooley M. Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease. BMC Nephrol. 2011 Jan 14; 12:2.

Zhang MH, Na B, Schiller NB, Whooley MA. Association of resistin with heart failure and mortality in patients with stable coronary heart disease: data from the heart and soul study. J Card Fail. 2011 Jan; 17(1):24-30.

Ku IA, Farzaneh-Far R, Vittinghoff E, Zhang MH, Na B, Whooley MA. Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study. Atherosclerosis. 2011 Aug; 217(2):503-8.

Kehl DW, Farzaneh-Far R, Na B, Whooley MA. Prognostic value of electrocardiographic detection of unrecognized myocardial infarction in persons with stable coronary artery disease: data from the Heart and Soul Study. Clin Res Cardiol. 2011 Apr; 100(4):359-66.

Habibzadeh MR, Farzaneh-Far R, Sarna P, Na B, Schiller NB, Whooley MA. Association of blood pressure and heart rate response during exercise with cardiovascular events in the Heart and Soul Study. J Hypertens. 2010 Nov; 28(11):2236-42.

Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study. PLoS One. 2010 Oct 20; 5(10):e13496.

Zhang MH, Na B, Schiller NB, Whooley MA. Resistin, exercise capacity, and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study. Atherosclerosis. 2010 Dec; 213(2):604-10.

von Känel R, Carney RM, Zhao S, Whooley MA. Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study. Clin Res Cardiol. 2011 Mar; 100(3):241-7.

Hoen PW, Whooley MA, Martens EJ, Na B, van Melle JP, de Jonge P. Differential associations between specific depressive symptoms and cardiovascular prognosis in patients with stable coronary heart disease. J Am Coll Cardiol. 2010 Sep 07; 56(11):838-44.

van Melle JP, Bot M, de Jonge P, de Boer RA, van Veldhuisen DJ, Whooley MA. Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study. Diabetes Care. 2010 Sep; 33(9):2084-9.

Deverts DJ, Cohen S, DiLillo VG, Lewis CE, Kiefe C, Whooley M, Matthews KA. Depressive symptoms, race, and circulating C-reactive protein: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Psychosom Med. 2010 Oct; 72(8):734-41.

Martens EJ, de Jonge P, Na B, Cohen BE, Lett H, Whooley MA. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease:The Heart and Soul Study. Arch Gen Psychiatry. 2010 Jul; 67(7):750-8.

Saab G, Whooley MA, Schiller NB, Ix JH. Association of serum phosphorus with left ventricular mass in men and women with stable cardiovascular disease: data from the Heart and Soul Study. Am J Kidney Dis. 2010 Sep; 56(3):496-505.

Pottala JV, Garg S, Cohen BE, Whooley MA, Harris WS. Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study. Circ Cardiovasc Qual Outcomes. 2010 Jul; 3(4):406-12.

Kangelaris KN, Vittinghoff E, Otte C, Na B, Auerbach AD, Whooley MA. Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. J Gen Intern Med. 2010 Oct; 25(10):1030-7.

Parker BD, Schurgers LJ, Brandenburg VM, Christenson RH, Vermeer C, Ketteler M, Shlipak MG, Whooley MA, Ix JH. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med. 2010 May 18; 152(10):640-8.

Whooley M, Unützer J. Interdisciplinary stepped care for depression after acute coronary syndrome. Arch Intern Med. 2010 Apr 12; 170(7):585-6.

Otte C, Wüst S, Zhao S, Pawlikowska L, Kwok PY, Whooley MA. Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study. J Clin Endocrinol Metab. 2010 Jun; 95(6):2885-91.

Marcus GM, Olgin JE, Whooley M, Vittinghoff E, Stone KL, Mehra R, Hulley SB, Schiller NB. Racial differences in atrial fibrillation prevalence and left atrial size. Am J Med. 2010 Apr; 123(4):375.e1-7.

Ix JH, de Boer IH, Wassel CL, Criqui MH, Shlipak MG, Whooley MA. Urinary creatinine excretion rate and mortality in persons with coronary artery disease: the Heart and Soul Study. Circulation. 2010 Mar 23; 121(11):1295-303.

Ristow B, Ali S, Na B, Turakhia MP, Whooley MA, Schiller NB. Predicting heart failure hospitalization and mortality by quantitative echocardiography: is body surface area the indexing method of choice? The Heart and Soul Study. J Am Soc Echocardiogr. 2010 Apr; 23(4):406-13.

Whooley O. Diagnostic ambivalence: psychiatric workarounds and the Diagnostic and Statistical Manual of Mental Disorders. Sociol Health Illn. 2010 Mar; 32(3):452-69.

Gehi A, Musselman D, Otte C, Bruce Royster E, Ali S, Whooley MA. Depression and platelet activation in outpatients with stable coronary heart disease: findings from the Heart and Soul Study. Psychiatry Res. 2010 Feb 28; 175(3):200-4.

Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA. 2010 Jan 20; 303(3):250-7.

Smith DT, Farzaneh-Far R, Ali S, Na B, Whooley MA, Schiller NB. Relation of beta-blocker use with frequency of hospitalization for heart failure in patients with left ventricular diastolic dysfunction (from the Heart and Soul Study). Am J Cardiol. 2010 Jan 15; 105(2):223-8.

Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA. Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One. 2010 Jan 08; 5(1):e8612.

Ix JH, Shlipak MG, Wassel CL, Whooley MA. Fibroblast growth factor-23 and early decrements in kidney function: the Heart and Soul Study. Nephrol Dial Transplant. 2010 Mar; 25(3):993-7.

Cohen BE, Panguluri P, Na B, Whooley MA. Psychological risk factors and the metabolic syndrome in patients with coronary heart disease: findings from the Heart and Soul Study. Psychiatry Res. 2010 Jan 30; 175(1-2):133-7.

McManus DD, Corteville DC, Shlipak MG, Whooley MA, Ix JH. Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study). Am J Cardiol. 2009 Dec 01; 104(11):1551-5.

Parker BD, Schurgers LJ, Vermeer C, Schiller NB, Whooley MA, Ix JH. The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study. Atherosclerosis. 2010 May; 210(1):320-5.

Cohen BE, Marmar CR, Neylan TC, Schiller NB, Ali S, Whooley MA. Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: findings from the Heart and Soul Study. Arch Gen Psychiatry. 2009 Nov; 66(11):1214-20.

Deo R, Shlipak MG, Ix JH, Ali S, Schiller NB, Whooley MA. Association of cystatin C with ischemia in patients with coronary heart disease. Clin Cardiol. 2009 Nov; 32(11):E18-22.

Spies C, Farzaneh-Far R, Na B, Kanaya A, Schiller NB, Whooley MA. Relation of obesity to heart failure hospitalization and cardiovascular events in persons with stable coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2009 Oct 01; 104(7):883-9.

Hsieh BP, Rogers AM, Na B, Wu AH, Schiller NB, Whooley MA. Prevalence and prognostic significance of incidental cardiac troponin T elevation in ambulatory patients with stable coronary artery disease: data from the Heart and Soul study. Am Heart J. 2009 Oct; 158(4):673-9.

Otte C, Wüst S, Zhao S, Pawlikowska L, Kwok PY, Whooley MA. Glucocorticoid receptor gene and depression in patients with coronary heart disease: the Heart and Soul Study-2009 Curt Richter Award Winner. Psychoneuroendocrinology. 2009 Nov; 34(10):1574-81.

Whooley MA. To screen or not to screen? Depression in patients with cardiovascular disease. J Am Coll Cardiol. 2009 Sep 01; 54(10):891-3.

Farzaneh-Far R, Na B, Whooley MA, Schiller NB. Left-ventricular power-to-mass ratio at peak exercise predicts mortality, heart failure, and cardiovascular events in patients with stable coronary artery disease: data from the Heart and Soul Study. Cardiology. 2009; 114(3):226-34.

Singh HS, Bibbins-Domingo K, Ali S, Wu AH, Schiller NB, Whooley MA. N-terminal pro-B-type natriuretic peptide and inducible ischemia in the Heart and Soul Study. Clin Cardiol. 2009 Aug; 32(8):447-53.

Turakhia MP, McManus DD, Whooley MA, Schiller NB. Increase in end-systolic volume after exercise independently predicts mortality in patients with coronary heart disease: data from the Heart and Soul Study. Eur Heart J. 2009 Oct; 30(20):2478-84.

Wulsin LR, Musselman D, Otte C, Bruce E, Ali S, Whooley MA. Depression and whole blood serotonin in patients with coronary heart disease from the Heart and Soul Study. Psychosom Med. 2009 Apr; 71(3):260-5.

Schenker Y, Stewart A, Na B, Whooley MA. Depressive symptoms and perceived doctor-patient communication in the Heart and Soul study. J Gen Intern Med. 2009 May; 24(5):550-6.

Sarkar U, Ali S, Whooley MA. Self-efficacy as a marker of cardiac function and predictor of heart failure hospitalization and mortality in patients with stable coronary heart disease: findings from the Heart and Soul Study. Health Psychol. 2009 Mar; 28(2):166-73.

Caska CM, Hendrickson BE, Wong MH, Ali S, Neylan T, Whooley MA. Anger expression and sleep quality in patients with coronary heart disease: findings from the Heart and Soul Study. Psychosom Med. 2009 Apr; 71(3):280-5.

Ali S, Garg SK, Cohen BE, Bhave P, Harris WS, Whooley MA. Association between omega-3 fatty acids and depressive symptoms among patients with established coronary artery disease: data from the Heart and Soul Study. Psychother Psychosom. 2009; 78(2):125-7.

Tsui JI, Whooley MA, Monto A, Seal K, Tien PC, Shlipak M. Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul study. J Card Fail. 2009 Jun; 15(5):451-6.

Parker BD, Ix JH, Cranenburg EC, Vermeer C, Whooley MA, Schurgers LJ. Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study. Nephrol Dial Transplant. 2009 Jul; 24(7):2095-101.

Colangelo LA, He K, Whooley MA, Daviglus ML, Liu K. Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women. Nutrition. 2009 Oct; 25(10):1011-9.

Stevens SM, Farzaneh-Far R, Na B, Whooley MA, Schiller NB. Development of an echocardiographic risk-stratification index to predict heart failure in patients with stable coronary artery disease: the Heart and Soul study. JACC Cardiovasc Imaging. 2009 Jan; 2(1):11-20.

Farzaneh-Far R, Na B, Schiller NB, Whooley MA. Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis. 2009 Aug; 205(2):492-6.

Ren X, Na B, Ristow B, Whooley MA, Schiller NB. Usefulness of diastolic dominant pulmonary vein flow to predict hospitalization for heart failure and mortality in ambulatory patients with coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2009 Feb 15; 103(4):482-5.

Farzaneh-Far R, Harris WS, Garg S, Na B, Whooley MA. Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis. 2009 Aug; 205(2):538-43.

McManus DD, Shah SJ, Fabi MR, Rosen A, Whooley MA, Schiller NB. Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: data from the Heart and Soul Study. J Am Soc Echocardiogr. 2009 Feb; 22(2):190-7.

Whooley MA, de Jonge P, Vittinghoff E, Otte C, Moos R, Carney RM, Ali S, Dowray S, Na B, Feldman MD, Schiller NB, Browner WS. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA. 2008 Nov 26; 300(20):2379-88.

Zhang MH, Spies C, Ali S, Kanaya AM, Schiller NB, Whooley MA. Adiponectin and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study. Atherosclerosis. 2009 Jul; 205(1):233-8.

Thombs BD, de Jonge P, Coyne JC, Whooley MA, Frasure-Smith N, Mitchell AJ, Zuidersma M, Eze-Nliam C, Lima BB, Smith CG, Soderlund K, Ziegelstein RC. Depression screening and patient outcomes in cardiovascular care: a systematic review. JAMA. 2008 Nov 12; 300(18):2161-71.

Thombs BD, Ziegelstein RC, Whooley MA. Optimizing detection of major depression among patients with coronary artery disease using the patient health questionnaire: data from the heart and soul study. J Gen Intern Med. 2008 Dec; 23(12):2014-7.

Turakhia MP, Schiller NB, Whooley MA. Prognostic significance of increased left ventricular mass index to mortality and sudden death in patients with stable coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2008 Nov 01; 102(9):1131-5.

Gehi AK, Ali S, Na B, Schiller NB, Whooley MA. Inducible ischemia and the risk of recurrent cardiovascular events in outpatients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2008 Jul 14; 168(13):1423-8.

Cohen BE, Garg SK, Ali S, Harris WS, Whooley MA. Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study. J Nutr. 2008 Jun; 138(6):1135-40.

Ristow B, Ali S, Whooley MA, Schiller NB. Usefulness of left atrial volume index to predict heart failure hospitalization and mortality in ambulatory patients with coronary heart disease and comparison to left ventricular ejection fraction (from the Heart and Soul Study). Am J Cardiol. 2008 Jul 01; 102(1):70-6.

Farzaneh-Far R, Cawthon RM, Na B, Browner WS, Schiller NB, Whooley MA. Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7):1379-84.

Lett H, Ali S, Whooley M. Depression and cardiac function in patients with stable coronary heart disease: findings from the Heart and Soul Study. Psychosom Med. 2008 May; 70(4):444-9.

Farzaneh-Far R, Na B, Whooley MA, Schiller NB. Usefulness of noninvasive estimate of pulmonary vascular resistance to predict mortality, heart failure, and adverse cardiovascular events in Patients With stable coronary artery disease (from the Heart and Soul Study). Am J Cardiol. 2008 Mar 15; 101(6):762-6.

Shlipak MG, Ix JH, Bibbins-Domingo K, Lin F, Whooley MA. Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study. Am J Med. 2008 Jan; 121(1):50-7.

Williams ES, Shah SJ, Ali S, Na BY, Schiller NB, Whooley MA. C-reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study. Eur J Heart Fail. 2008 Jan; 10(1):63-9.

Cohen B, Vittinghoff E, Whooley M. Association of socioeconomic status and exercise capacity in adults with coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2008 Feb 15; 101(4):462-6.

Marcus GM, Whooley MA, Glidden DV, Pawlikowska L, Zaroff JG, Olgin JE. Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul Study. Am Heart J. 2008 Feb; 155(2):303-9.

de Jonge P, Mangano D, Whooley MA. Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Psychosom Med. 2007 Nov; 69(8):735-9.

Gehi AK, Ali S, Na B, Whooley MA. Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2007 Sep 10; 167(16):1798-803.

Otte C, McCaffery J, Ali S, Whooley MA. Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study. Am J Psychiatry. 2007 Sep; 164(9):1379-84.

Desai AS, Bibbins-Domingo K, Shlipak MG, Wu AH, Ali S, Whooley MA. Association between anaemia and N-terminal pro-B-type natriuretic peptide (NT-proBNP): findings from the Heart and Soul Study. Eur J Heart Fail. 2007 Sep; 9(9):886-91.

Khush KK, Shah SJ, Ristow B, De Marco T, Whooley MA, Schiller NB. Association of African American race with elevated pulmonary artery diastolic pressure: data from the Heart and Soul Study. J Am Soc Echocardiogr. 2007 Nov; 20(11):1307-13.

Diem SJ, Blackwell TL, Stone KL, Yaffe K, Cauley JA, Whooley MA, Ensrud KE. Depressive symptoms and rates of bone loss at the hip in older women. J Am Geriatr Soc. 2007 Jun; 55(6):824-31.

Sarkar U, Ali S, Whooley MA. Self-efficacy and health status in patients with coronary heart disease: findings from the heart and soul study. Psychosom Med. 2007 May; 69(4):306-12.

Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA. Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007 May 15; 115(19):2533-9.

Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8461-6.

Ren X, Ristow B, Na B, Ali S, Schiller NB, Whooley MA. Prevalence and prognosis of asymptomatic left ventricular diastolic dysfunction in ambulatory patients with coronary heart disease. Am J Cardiol. 2007 Jun 15; 99(12):1643-7.

Whooley MA, Caska CM, Hendrickson BE, Rourke MA, Ho J, Ali S. Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study. Biol Psychiatry. 2007 Aug 15; 62(4):314-20.

Corteville DC, Bibbins-Domingo K, Wu AH, Ali S, Schiller NB, Whooley MA. N-terminal pro-B-type natriuretic peptide as a diagnostic test for ventricular dysfunction in patients with coronary disease: data from the heart and soul study. Arch Intern Med. 2007 Mar 12; 167(5):483-9.

McManus D, Shlipak M, Ix JH, Ali S, Whooley MA. Association of cystatin C with poor exercise capacity and heart rate recovery: data from the heart and soul study. Am J Kidney Dis. 2007 Mar; 49(3):365-72.

Shah SJ, Ristow B, Ali S, Na BY, Schiller NB, Whooley MA. Acute myocardial infarction in patients with versus without aortic valve sclerosis and effect of statin therapy (from the Heart and Soul Study). Am J Cardiol. 2007 Apr 15; 99(8):1128-33.

Bibbins-Domingo K, Gupta R, Na B, Wu AH, Schiller NB, Whooley MA. N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease. JAMA. 2007 Jan 10; 297(2):169-76.

Singh D, Whooley MA, Ix JH, Ali S, Shlipak MG. Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study. Nephrol Dial Transplant. 2007 Apr; 22(4):1087-92.

Ix JH, Shlipak MG, Chertow GM, Whooley MA. Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007 Jan 16; 115(2):173-9.

Ristow B, Ali S, Ren X, Whooley MA, Schiller NB. Elevated pulmonary artery pressure by Doppler echocardiography predicts hospitalization for heart failure and mortality in ambulatory stable coronary artery disease: the Heart and Soul Study. J Am Coll Cardiol. 2007 Jan 02; 49(1):43-9.

Ix JH, Shlipak MG, Chertow GM, Ali S, Schiller NB, Whooley MA. Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study. J Card Fail. 2006 Oct; 12(8):601-7.

Peralta CA, Whooley MA, Ix JH, Shlipak MG. Kidney function and systolic blood pressure new insights from cystatin C: data from the Heart and Soul Study. Am J Hypertens. 2006 Sep; 19(9):939-46.

Whooley MA. Depression and cardiovascular disease: healing the broken-hearted. JAMA. 2006 Jun 28; 295(24):2874-81.

Whooley MA. Mind your heart. Ann Intern Med. 2006 Jun 06; 144(11):858-60.

Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA. Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study. Nephrol Dial Transplant. 2006 Aug; 21(8):2144-51.

Ix JH, Shlipak MG, Brandenburg VM, Ali S, Ketteler M, Whooley MA. Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation. 2006 Apr 11; 113(14):1760-7.

Matthews KA, Zhu S, Tucker DC, Whooley MA. Blood pressure reactivity to psychological stress and coronary calcification in the Coronary Artery Risk Development in Young Adults Study. Hypertension. 2006 Mar; 47(3):391-5.

Knox S, Barnes A, Kiefe C, Lewis CE, Iribarren C, Matthews KA, Wong ND, Whooley M. History of depression, race, and cardiovascular risk in CARDIA. Int J Behav Med. 2006; 13(1):44-50.

Odden MC, Whooley MA, Shlipak MG. Depression, stress, and quality of life in persons with chronic kidney disease: the Heart and Soul Study. Nephron Clin Pract. 2006; 103(1):c1-7.

Gehi A, Haas D, Pipkin S, Whooley MA. Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study. Arch Intern Med. 2005 Nov 28; 165(21):2508-13.

Otte C, Neylan TC, Pipkin SS, Browner WS, Whooley MA. Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Am J Psychiatry. 2005 Nov; 162(11):2139-45.

Rumsfeld JS, Jones PG, Whooley MA, Sullivan MD, Pitt B, Weintraub WS, Spertus JA. Depression predicts mortality and hospitalization in patients with myocardial infarction complicated by heart failure. Am Heart J. 2005 Nov; 150(5):961-7.

Lubbock LA, Goh A, Ali S, Ritchie J, Whooley MA. Relation of low socioeconomic status to C-reactive protein in patients with coronary heart disease (from the heart and soul study). Am J Cardiol. 2005 Dec 01; 96(11):1506-11.

Ristow B, Ahmed S, Wang L, Liu H, Angeja BG, Whooley MA, Schiller NB. Pulmonary regurgitation end-diastolic gradient is a Doppler marker of cardiac status: data from the Heart and Soul Study. J Am Soc Echocardiogr. 2005 Sep; 18(9):885-91.

McManus D, Pipkin SS, Whooley MA. Screening for depression in patients with coronary heart disease (data from the Heart and Soul Study). Am J Cardiol. 2005 Oct 15; 96(8):1076-81.

Gehi A, Ix J, Shlipak M, Pipkin SS, Whooley MA. Relation of anemia to low heart rate variability in patients with coronary heart disease (from the Heart and Soul study). Am J Cardiol. 2005 Jun 15; 95(12):1474-7.

Gehi A, Mangano D, Pipkin S, Browner WS, Whooley MA. Depression and heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Arch Gen Psychiatry. 2005 Jun; 62(6):661-6.

Spies C, Otte C, Kanaya A, Pipkin SS, Schiller NB, Whooley MA. Association of metabolic syndrome with exercise capacity and heart rate recovery in patients with coronary heart disease in the heart and soul study. Am J Cardiol. 2005 May 15; 95(10):1175-9.

Nair D, Shlipak MG, Angeja B, Liu HH, Schiller NB, Whooley MA. Association of anemia with diastolic dysfunction among patients with coronary artery disease in the Heart and Soul Study. Am J Cardiol. 2005 Feb 01; 95(3):332-6.

Odden MC, Whooley MA, Shlipak MG. Association of chronic kidney disease and anemia with physical capacity: the heart and soul study. J Am Soc Nephrol. 2004 Nov; 15(11):2908-15.

Pham MX, Whooley MA, Evans GT, Liu C, Emadi H, Tong W, Murphy MC, Fleischmann KE. Prognostic value of low-level cardiac troponin-I elevations in patients without definite acute coronary syndromes. Am Heart J. 2004 Nov; 148(5):776-82.

Otte C, Marmar CR, Pipkin SS, Moos R, Browner WS, Whooley MA. Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study. Biol Psychiatry. 2004 Aug 15; 56(4):241-7.

Markovitz JH, Matthews KA, Whooley M, Lewis CE, Greenlund KJ. Increases in job strain are associated with incident hypertension in the CARDIA Study. Ann Behav Med. 2004 Aug; 28(1):4-9.

Ruo B, Rumsfeld JS, Pipkin S, Whooley MA. Relation between depressive symptoms and treadmill exercise capacity in the Heart and Soul Study. Am J Cardiol. 2004 Jul 01; 94(1):96-9.

Matthews KA, Katholi CR, McCreath H, Whooley MA, Williams DR, Zhu S, Markovitz JH. Blood pressure reactivity to psychological stress predicts hypertension in the CARDIA study. Circulation. 2004 Jul 06; 110(1):74-8.

Whooley MA, Cauley JA, Zmuda JM, Haney EM, Glynn NW. Depressive symptoms and bone mineral density in older men. J Geriatr Psychiatry Neurol. 2004 Jun; 17(2):88-92.

Bibbins-Domingo K, Ansari M, Schiller NB, Massie B, Whooley MA. Is B-type natriuretic peptide a useful screening test for systolic or diastolic dysfunction in patients with coronary disease? Data from the Heart and Soul Study. Am J Med. 2004 Apr 15; 116(8):509-16.

Fihn SD, McDonell MB, Diehr P, Anderson SM, Bradley KA, Au DH, Spertus JA, Burman M, Reiber GE, Kiefe CI, Cody M, Sanders KM, Whooley MA, Rosenfeld K, Baczek LA, Sauvigne A. Effects of sustained audit/feedback on self-reported health status of primary care patients. Am J Med. 2004 Feb 15; 116(4):241-8.

Bibbins-Domingo K, Ansari M, Schiller NB, Massie B, Whooley MA. B-type natriuretic peptide and ischemia in patients with stable coronary disease: data from the Heart and Soul study. Circulation. 2003 Dec 16; 108(24):2987-92.

Ix JH, Shlipak MG, Liu HH, Schiller NB, Whooley MA. Association between renal insufficiency and inducible ischemia in patients with coronary artery disease: the heart and soul study. J Am Soc Nephrol. 2003 Dec; 14(12):3233-8.

Gehi AK, Rumsfeld JS, Liu H, Schiller NB, Whooley MA. Relation of self-reported angina pectoris to inducible myocardial ischemia in patients with known coronary artery disease: the Heart and Soul Study. Am J Cardiol. 2003 Sep 15; 92(6):705-7.

Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA. 2003 Jul 09; 290(2):215-21.

Mehta KM, Yaffe K, Langa KM, Sands L, Whooley MA, Covinsky KE. Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. J Gerontol A Biol Sci Med Sci. 2003 May; 58(5):M461-7.

Ensrud KE, Blackwell T, Mangione CM, Bowman PJ, Bauer DC, Schwartz A, Hanlon JT, Nevitt MC, Whooley MA. Central nervous system active medications and risk for fractures in older women. Arch Intern Med. 2003 Apr 28; 163(8):949-57.

Beattie MS, Shlipak MG, Liu H, Browner WS, Schiller NB, Whooley MA. C-reactive protein and ischemia in users and nonusers of beta-blockers and statins: data from the Heart and Soul Study. Circulation. 2003 Jan 21; 107(2):245-50.

Whooley MA, Kiefe CI, Chesney MA, Markovitz JH, Matthews K, Hulley SB. Depressive symptoms, unemployment, and loss of income: The CARDIA Study. Arch Intern Med. 2002 Dec 9-23; 162(22):2614-20.

Ensrud KE, Blackwell TL, Mangione CM, Bowman PJ, Whooley MA, Bauer DC, Schwartz AV, Hanlon JT, Nevitt MC. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc. 2002 Oct; 50(10):1629-37.

Whooley MA, Boyd AL, Gardin JM, Williams DR. Religious involvement and cigarette smoking in young adults: the CARDIA study (Coronary Artery Risk Development in Young Adults)study (. Arch Intern Med. 2002 Jul 22; 162(14):1604-10.

Hlatky MA, Boothroyd D, Vittinghoff E, Sharp P, Whooley MA. Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial. JAMA. 2002 Feb 06; 287(5):591-7.

Whooley MA, Simon GE. Managing depression in medical outpatients. N Engl J Med. 2000 Dec 28; 343(26):1942-50.

Whooley MA, Grady D, Cauley JA. Postmenopausal estrogen therapy and depressive symptoms in older women. J Gen Intern Med. 2000 Aug; 15(8):535-41.

Whooley MA, Stone B, Soghikian K. Randomized trial of case-finding for depression in elderly primary care patients. J Gen Intern Med. 2000 May; 15(5):293-300.

Saha S, Christakis DA, Saint S, Whooley MA, Simon SR. A survival guide for generalist physicians in academic fellowships part 1: getting started. J Gen Intern Med. 1999 Dec; 14(12):745-9.

Whooley MA. Depression and medical illness. Ann Epidemiol. 1999 Jul; 9(5):281-2.

Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS. Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1999 Mar 08; 159(5):484-90.

Whooley MA, Browner WS. Association between depressive symptoms and mortality in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1998 Oct 26; 158(19):2129-35.

Yaffe K, Ettinger B, Pressman A, Seeley D, Whooley M, Schaefer C, Cummings S. Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study. Biol Psychiatry. 1998 May 01; 43(9):694-700.

Whooley MA, Grady D, Cummings SR. Postmenopausal hormone therapy and mortality. N Engl J Med. 1997 Nov 06; 337(19):1389-90; author reply 1391.

Whooley MA, Avins AL, Miranda J, Browner WS. Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med. 1997 Jul; 12(7):439-45.

Tierney LM, Whooley MA, Saint S. Oxygen saturation: a fifth vital sign? West J Med. 1997 Apr; 166(4):285-6.

Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA. 1996 Sep 11; 276(10):811-5.

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